Evidence map›Paper›PMID 36849677›Full record

ArticleGeroScience2023

The impacts of social determinants of health and cardiometabolic factors on cognitive and functional aging in Colombian underserved populations.

Hernando Santamaria-Garcia, Sebastian Moguilner, Odir Antonio Rodriguez-Villagra, Felipe Botero-Rodriguez, Stefanie Danielle Pina-Escudero, Gary O'Donovan, Cecilia Albala, Diana Matallana, Michael Schulte, Andrea Slachevsky and 9 more

Open access · hybridAbstract read
In one paragraph

Article in GeroScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Memory and aging across cultures.Current opinion in psychology · 2024
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 9 countries.

Hernando Santamaria-GarciaGlobal Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA. hernando.santamaria@gbhi.org.
Sebastian MoguilnerLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Odir Antonio Rodriguez-VillagraInstitute for Psychological Research, University of Costa Rica, Sabanilla, Costa Rica.
Felipe Botero-RodriguezPontificia Universidad Javeriana (Ph.D. Program in Neuroscience, Department of Psychiatry), Bogotá, Colombia.
Stefanie Danielle Pina-EscuderoGlobal Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA.
Gary O'DonovanLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Cecilia AlbalaInstituto de Nutrición Y Tecnología de los Alimentos, Universidad de Chile, Avenida El Líbano 5524, Macul, Santiago, Chile.
Diana MatallanaPontificia Universidad Javeriana (Ph.D. Program in Neuroscience, Department of Psychiatry), Bogotá, Colombia.
Michael SchulteLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Andrea SlachevskyNeuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Department - Institute of Biomedical Sciences (ICBM), Neurocience and East Neuroscience Departments, Faculty of Medicine, University of Chile, Santiago de Chile, Chile.
Jennifer S YokoyamaGlobal Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA.
Katherine PossinGlobal Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA.
Lishomwa C NdhlovuDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.
Tala Al-RousanHerbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA.
Michael J CorleyDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.
Kenneth S KosikNeuroscience Research Institute. Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA, USA.
Graciela Muniz-TerreraEdinburgh Dementia Prevention, University of Edinburgh, Edinburgh, UK.
J Jaime MirandaCRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru.
Agustin IbanezGlobal Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, CA, USA. agustin.ibanez@gbhi.org.ORCID 0000-0001-6758-5101
University of California, San Francisco · USCornell University · USPontificia Universidad Javeriana · COAdolfo Ibáñez University · CLConsejo Nacional de Investigaciones Científicas y Técnicas · ARHarvard University · USOhio University · USUniversidad de Costa Rica · CRUniversidad del Desarrollo · CLUniversidad de Los Andes · COUniversidad Peruana Cayetano Heredia · PEUniversity of California San Diego · USUniversity of California, Santa Barbara · USUniversity of Chile · CL

Funding

Household Air Pollution and Health: A Multi-Country LPG Intervention TrialUM1HL134590 · NHLBI · EMORY UNIVERSITY · PI CHECKLEY, WILLIAM, CLASEN, THOMAS F · 2016 to 2021
$31.1M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
Latin America Treatment & Innovation Network in Mental Health (LATIN-MH)U19MH098780 · NIMH · FUNDACAO FACULDADE DE MEDICINA · PI ARAYA, RICARDO, MENEZES, PAULO ROSSI · 2013 to 2017
$2.7M
Investigating Cellular Immunometabolic Mechanisms Underlying HIV-Related Cardiovascular Disease RiskR01HL160392 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CORLEY, MICHAEL JAY · 2021 to 2024
$2.3M
Launching a salt substitute to reduce blood pressure at the population level-PeruU01HL114180 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2012 to 2016
$2.0M
Blood Pressure Control Advancing Refugee Health Equity (BPCARE): an RCT of adherenceR01HL173155 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Tala Al-Rousan · 2025 to 2026
$1.3M
Hypertension Self-management in Refugees Living in San DiegoK23HL148530 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AL-ROUSAN, TALA · 2020 to 2024
$882k
The role of epigenetic transcriptional memory in monocyte-macrophage cells and cardiovascular disease riskK01HL140271 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CORLEY, MICHAEL JAY · 2018 to 2022
$788k
Building sustainable and innovative research in Cancer and Cardiovascular disease: Planning the design and development of the South American Center of Research Excellence to Counter NCDs (SACREN)P20CA217231 · NCI · INSTITUTO DE EFECTIVIDAD CLINICA Y SANIT · PI IRAZOLA, VILMA · 2017 to 2018
$497k
Implementation of foot thermometry and SMS to prevent diabetic foot ulcerR21TW009982 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI MIRANDA, J JAIME · 2014 to 2015
$329k
Using Burden of Treatment as a Clinical Indicator of Barriers to Multimorbidity Management in Peru: A Mixed Methods ApproachR21TW011740 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI CUBA , MARIA SOFIA · 2020 to 2021
$297k
Planning to Establish a Regional Center of NCD Research Training in PeruD71TW010877 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI MIRANDA, J JAIME · 2017 to 2017
$50k
FIC NIH HHS D71 TW010877FIC NIH HHS R21 TW009982FIC NIH HHS R21 TW011740Medical Research Council MR/M007405/1Medical Research Council MR/P02386X/1Medical Research Council MR/P024408/1NCI NIH HHS P20 CA217231NHLBI NIH HHS K01 HL140271NHLBI NIH HHS K23 HL148530NHLBI NIH HHS R01 HL160392NHLBI NIH HHS R01 HL173155NHLBI NIH HHS U01 HL114180NHLBI NIH HHS UM1 HL134590NIA NIH HHS R01 AG057234NIMH NIH HHS U19 MH098780Wellcome Trust 074833/Z/04/ZWellcome Trust 093541/Z/10/ZWellcome Trust 103994/Z/14/ZWellcome Trust 107435/Z/15/ZWellcome Trust 205177/Z/16/ZWellcome Trust 214185/Z/18/ZWellcome Trust 218743/Z/19/ZWellcome Trust MR/M007405/1
6 · The paper itself

Abstract

Global initiatives call for further understanding of the impact of inequity on aging across underserved populations. Previous research in low- and middle-income countries (LMICs) presents limitations in assessing combined sources of inequity and outcomes (i.e., cognition and functionality). In this study, we assessed how social determinants of health (SDH), cardiometabolic factors (CMFs), and other medical/social factors predict cognition and functionality in an aging Colombian population. We ran a cross-sectional study that combined theory- (structural equation models) and data-driven (machine learning) approaches in a population-based study (N = 23,694; M = 69.8 years) to assess the best predictors of cognition and functionality. We found that a combination of SDH and CMF accurately predicted cognition and functionality, although SDH was the stronger predictor. Cognition was predicted with the highest accuracy by SDH, followed by demographics, CMF, and other factors. A combination of SDH, age, CMF, and additional physical/psychological factors were the best predictors of functional status. Results highlight the role of inequity in predicting brain health and advancing solutions to reduce the cognitive and functional decline in LMICs.

Indexed as

Cardiovascular DiseasesSocial FactorsAgingCognitionColombiaCross-Sectional StudiesHumansSocial Determinants of HealthVulnerable PopulationsCardiometabolic factorsCognitionFunctionalityNational Aging Population SurveySocial determinants of Health

Identifiers

PMID36849677
PMCPMC10651610
OpenAlexW4322487142

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.