ArticleNature metabolism2023
Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle.
Article in Nature metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 35 citations in OpenAlex.
- uORF-mediated translational control of CAK and Cdk activation in response to low nutrients in yeast.EMBO reports · 2026Article
- Cell cycle-dependent protein dynamics in budding yeast resolved by deconvolution of bulk proteomics.Molecular systems biology · 2026Article
- Metabolic Reprogramming and Proteome Reallocation Accompany Loss of Respiratory Oscillations in Yeast Accelerostat.Biotechnology and bioengineering · 2026Article
- The Yeast Metabolic Cycle as a Tractable Cellular Framework for Redox Timing, Redox Buffering, and Transcriptome Fidelity.Antioxidants (Basel, Switzerland) · 2026Article
- SNF1/AMPK controls its own localization by phosphorylating its activating kinase Sak1.iScience · 2026Article
- Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates.Nature communications · 2026Article
- Love-thy-neighbor: Neural networks for tracking and lineage tracing in budding yeast.bioRxiv : the preprint server for biology · 2026Article
- Love-thy-neighbor: neural networks for tracking and lineage tracing in budding yeast.Bioinformatics advances · 2026Article
- CHK1 as a Metabolic and Immunological Regulator: Implications for Cancer Therapy.Oncology research · 2026Review
- Energetics of whole genome doubling and genomic instability.Cancer letters · 2025Review
- Temporal oscillation of phospholipids promotes metabolic efficiency.Nature chemical biology · 2025Article
- The hepatic clock synergizes with HIF-1α to regulate nucleotide availability during liver damage repair.Nature metabolism · 2025Article
- Understanding metabolic plasticity at single cell resolution.Essays in biochemistry · 2024Review
- Hypothesis: bacteria live on the edge of phase transitions with a cell cycle regulated by a water-clock.Theory in biosciences = Theorie in den Biowissenschaften · 2024Article
- The "weaken-fill-repair" model for cell budding: Linking cell wall biosynthesis with mechanics.iScience · 2024Article
- Historic obstacles and emerging opportunities in the field of developmental metabolism - lessons from Heidelberg.Development (Cambridge, England) · 2024Review
- APC/C-regulated CPT1C promotes tumor progression by upregulating the energy supply and accelerating the G1/S transition.Cell communication and signaling : CCS · 2024Article
- Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells.Cell reports · 2024Article
- Patterns of protein synthesis in the budding yeast cell cycle: variable or constant?Microbial cell (Graz, Austria) · 2024Article
- Cross Talk Between Metabolism and the Cell Division Cycle.Methods in molecular biology (Clifton, N.J.) · 2024Article
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many cell biological and biochemical mechanisms controlling the fundamental process of eukaryotic cell division have been identified; however, the temporal dynamics of biosynthetic processes during the cell division cycle are still elusive. Here, we show that key biosynthetic processes are temporally segregated along the cell cycle. Using budding yeast as a model and single-cell methods to dynamically measure metabolic activity, we observe two peaks in protein synthesis, in the G1 and S/G2/M phase, whereas lipid and polysaccharide synthesis peaks only once, during the S/G2/M phase. Integrating the inferred biosynthetic rates into a thermodynamic-stoichiometric metabolic model, we find that this temporal segregation in biosynthetic processes causes flux changes in primary metabolism, with an acceleration of glucose-uptake flux in G1 and phase-shifted oscillations of oxygen and carbon dioxide exchanges. Through experimental validation of the model predictions, we demonstrate that primary metabolism oscillates with cell-cycle periodicity to satisfy the changing demands of biosynthetic processes exhibiting unexpected dynamics during the cell cycle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.