Evidence map›Paper›PMID 36851322›Full record

ArticleVaccines2023

Yellow Fever Vaccine-Related Neurotropic Disease in Brazil Following Immunization with 17DD.

Flora de Andrade Gandolfi, Cassia Fernanda Estofolete, Marcia Catelan Wakai, Andreia Francesli Negri, Michela Dias Barcelos, Nikos Vasilakis, Mauricio Lacerda Nogueira

Abstract readCase Reports
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A Systematic Review on Yellow Fever Vaccine and Adverse Events.Global health, epidemiology and genomics · 2026
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Flora de Andrade GandolfiLaboratório de Pesquisas em Virologia (LPV), Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0001-9815-8479
Cassia Fernanda EstofoleteLaboratório de Pesquisas em Virologia (LPV), Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0001-7324-1591
Marcia Catelan WakaiHospital da Criança e Maternidade de São José do Rio Preto, São José do Rio Preto 15091-240, SP, Brazil.
Andreia Francesli NegriHospital de Base de São José do Rio Preto, São José do Rio Preto 15090-000, SP, Brazil.
Michela Dias BarcelosHospital de Base de São José do Rio Preto, São José do Rio Preto 15090-000, SP, Brazil.
Nikos VasilakisDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-0708-3289
Mauricio Lacerda NogueiraLaboratório de Pesquisas em Virologia (LPV), Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.ORCID 0000-0003-1102-2419

Funding

Coordinating Research on Emerging Arboviral Threats Encompassing the Neotropics II (CREATE-NEO II)U01AI151807 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Kathryn Alyce Hanley, MAURICIO Lacerda NOGUEIRA · 2020 to 2026
$9.8M
NIAID NIH HHS U01 AI151807
6 · The paper itself

Abstract

The disease burden of yellow fever virus infection (YFV) is quite high in the tropics where vaccination coverage is low. To date, vaccination is the most effective control strategy to mitigate and eliminate the burden of YF disease. The licensed YF vaccines are safe and effective and serious adverse events are rare. Herein, we report three cases of neurological syndrome, compatible with meningoencephalitis following 17DD vaccination. In all cases, YFV-specific IgM antibodies were detected in the cerebrospinal fluid. Our observations confirm the development of YF vaccine-associated neurotropic disease, a rare serious adverse event, from which all three patients have fully recovered without any long-term sequelae. This report reinforces the need for awareness among health professionals to recognize and effectively manage such events in a timely manner.

Indexed as

neurotropic disorderserious adverse eventsvaccineyellow fever

Identifiers

PMID36851322
PMCPMC9962731

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.