Evidence map›Paper›PMID 36853582›Full record

ArticleResearch on child and adolescent psychopathology2023

Interpersonal Life Stress and Inflammatory Reactivity as Prospective Predictors of Suicide Attempts in Adolescent Females.

Matthew G Clayton, Benjamin W Nelson, Matteo Giletta, Paul D Hastings, Matthew K Nock, Karen D Rudolph, George M Slavich, Mitchell J Prinstein

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research on child and adolescent psychopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Matthew G ClaytonDepartment of Psychology and Neuroscience, UNC Psychology and Neuroscience, University of North Carolina at Chapel Hill, Davie Hall, Campus Box 3270, 27599-3270, 962-3988, Chapel Hill, NC, USA. mgc12@live.unc.edu.ORCID 0000-0002-6748-5714
Benjamin W NelsonDepartment of Psychology and Neuroscience, UNC Psychology and Neuroscience, University of North Carolina at Chapel Hill, Davie Hall, Campus Box 3270, 27599-3270, 962-3988, Chapel Hill, NC, USA.
Matteo GilettaDepartment of Psychology, Ghent University, Ghent, Belgium.
Paul D HastingsCenter for Mind and Brain, Department of Psychology, University of California, Davis, CA, USA.
Matthew K NockDepartment of Psychology, Harvard University, Boston, MA, USA.
Karen D RudolphDepartment of Psychology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
George M SlavichCousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
Mitchell J PrinsteinDepartment of Psychology and Neuroscience, UNC Psychology and Neuroscience, University of North Carolina at Chapel Hill, Davie Hall, Campus Box 3270, 27599-3270, 962-3988, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USHarvard University · USTilburg University · NLUniversity of California, Davis · USUniversity of California, Los Angeles · USUniversity of Illinois Urbana-Champaign · US

Funding

Multilevel Biomarkers for Suicidal Behavior: From Interpersonal Stress to Gene Expression in a Longitudinal Study of Adolescent GirlsR01MH107479 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NOCK, MATTHEW K, PRINSTEIN, MITCHELL J · 2015 to 2019
$4.6M
Neural, Inflammatory, and Genomic Mechanisms Underlying Risk for Depression in AdolescenceK08MH103443 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLAVICH, GEORGE MICHAEL · 2015 to 2018
$772k
NIMH NIH HHS K08 MH103443NIMH NIH HHS K08MH103443NIMH NIH HHS R01 MH107479NIMH NIH HHS R01MH107479
6 · The paper itself

Abstract

Adolescents' suicidal behavior frequently is preceded by interpersonal stress, but not all who experience distress attempt to end their lives. Recent theories have posited individual differences in stress-related inflammatory reactivity may be associated with psychopathology risk; this study examined inflammatory reactivity as a moderator of the prospective association between interpersonal stress and adolescents' suicidal behavior. Participants included 157 at-risk adolescent females (ages 12 to 16 years) and assessed individual differences in proinflammatory cytokine responses to a brief laboratory-based social stressor, both interpersonal and non-interpersonal life events, and suicidal behavior over an 18-month follow-up period. Measuring levels of the key proinflammatory cytokines interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) before and after an experimentally-induced social stressor, results revealed that blunted cytokine reactivity heightened the effect of high interpersonal stress exposure on risk for suicidal behaviors over the subsequent 9 months. Significant effects were not revealed for non-interpersonally themed stress. Finding highlight the urgent need for more research examining inflammation reactivity among adolescents.

Indexed as

CytokinesSuicide, AttemptedAdolescentFemaleHumansInflammationInterleukin-6Stress, PsychologicalSuicidal IdeationCytokinesInterleukin-6AdolescenceCytokinesInflammationLife stressSocial stressSuicide

Identifiers

PMID36853582
PMCPMC10330793
OpenAlexW4322617740

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.