ArticleJournal of endocrinological investigation2023
Association between sarcopenia and prediabetes among non-elderly US adults.
Article in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Association of frailty index with sarcopenia: Mediation analysis of triglyceride-glucose-related indices: a cross-sectional study.Medicine · 2026Article
- Investigating the association between the food inflammation scores of individuals and stroke in adults: an extreme gradient boosting machine learning model interpreted with shapley additive explanations.Journal of health, population, and nutrition · 2026Article
- Multi-Axis Reprogramming of Muscle-Metabolic Crosstalk by HiLo Platinum™ Restores Strength in Prediabetes via Mitochondrial Activation and Gut Microbiome Remodeling.International journal of molecular sciences · 2026Article
- Associations of Body Composition and Physical Function With Incident Diabetes in Older Adults: A 14-Year Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Association between CVAI-defined body composition phenotypes and prediabetes outcomes in Chinese adults undergoing health check-ups: a cross-sectional study.Frontiers in nutrition · 2026Article
- Association of lipid accumulation product with the prevalence and incidence of sarcopenia: a nationwide study in Chinese.Nutrition & metabolism · 2025Article
- The relationship between sarcopenic obesity and prediabetes in adolescents: Analysis of the national health and nutrition examination survey from 2011 to 2016.Journal of clinical & translational endocrinology · 2025Article
- Exploring the link between osteosarcopenia and osteoarthritis in prediabetic adults using NHANES data.Scientific reports · 2025Article
- Antioxidant Diets and Lifestyles Could Mitigate the Risk of Sarcopenia with Low Muscle Mass in Women: A Retrospective Study.Healthcare (Basel, Switzerland) · 2025Article
- Gender-Specific Associations of Muscle Strength With Diabetic Retinopathy in Middle-Aged and Older Chinese Adults: A Cross-Sectional Study.International journal of endocrinology · 2025Article
- Nonlinear Association Between Red Cell Distribution Width-to-Albumin Ratio and Retinopathy: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2025Article
- The association of HALP score with low muscle mass in older adults.Frontiers in nutrition · 2025Article
- Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- The ZJU index is associated with the risk of sarcopenia in American adults aged 20-59: a cross-sectional study.Lipids in health and disease · 2024Article
- Association between sleep duration and sleep quality with pre-sarcopenia in the 20-59-year-old population: evidence from the National Health and Nutrition Examination Surveys 2005-2014.Archives of public health = Archives belges de sante publique · 2024Article
- Correlation study between bone metabolic markers, bone mineral density, and sarcopenia.Journal of endocrinological investigation · 2024Article
- The association between weight-adjusted-waist index and sarcopenia in adults: a population-based study.Scientific reports · 2024Article
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Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo explore the specific association between sarcopenia and prediabetes based on large population samples.
methodsA total of 16,116 U.S. adults aged 20-59 with dual energy X-ray absorptiometry (DXA) was identified from the National Health and Nutrition Examination Surveys (NHANES). Sarcopenia was defined according to appendicular skeletal muscle mass (ASM) adjusted for body mass index (BMI). Multivariable binary logistic regression models were used to ascertain odds ratios (ORs) for developing prediabetes. Stratified analyses were also performed.
resultsPrevalence of prediabetes was higher in the sarcopenia group (n = 1055) compared with the non-sarcopenia group (n = 15,061) (45.50% vs 28.74%, P < 0.001). Sarcopenia was strongly associated with an increased risk of prediabetes after full adjustment (OR = 1.21, 95CI%: 1.05, 1.39, P = 0.009). In the stratified analysis, this association remained significant independent of obesity, triglycerides, and low-density lipoprotein cholesterol levels. When sarcopenia subjects combined with obesity especially central obesity, the risk of prediabetes was the highest (OR = 2.63, 95CI%: 2.22, 3.11, P < 0.001). Furthermore, a greater proportion of any of impaired glucose tolerance (IGT) individuals was observed in the sarcopenia group compared to the non-sarcopenia group among prediabetes population (41.72% vs 24.06%, P < 0.001).
conclusionsSarcopenia was positively associated with prevalent prediabetes especially IGT in the non-elderly. Moreover, synergistic interactions between the sarcopenia and obesity could greatly increase the risk of prediabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.