Evidence map›Paper›PMID 36856989›Full record

ArticleObesity surgery2023

Parental Obesity Predisposition and Age of Onset Associate with Poor Response to Bariatric and Metabolic Surgery.

Mira Fink, Stephan Herrmann, Jodok Fink, Claudia Lässle, Goran Marjanovic, Luca Fagnocchi, J Andrew Pospisilik, Stefan Fichtner-Feigl, Gabriel Seifert

Abstract read
In one paragraph

Article in Obesity surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mira FinkDepartment of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Stephan HerrmannDepartment of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Jodok FinkDepartment of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Claudia LässleDepartment of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Goran MarjanovicDepartment of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Luca FagnocchiDepartment of Epigenetics, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA.
J Andrew PospisilikDepartment of Epigenetics, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA.
Stefan Fichtner-FeiglDepartment of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.
Gabriel SeifertDepartment of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany. gabriel.seifert@uniklinik-freiburg.de.ORCID http://orcid.org/0000-0003-3771-2186

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionParental predisposition and age of onset may be independently associated with 1-year total weight loss (TWL) failure (< 20%) after metabolic-bariatric surgery (MBS).

methodsThis cohort study includes all cases of the German StuDoQ|MBE register (2015-2019) with data on parental predisposition, obesity onset, and at least 1-year follow up after primary MBS procedures (n = 14,404). We provide descriptive statistics of the cohort in terms of the main outcome and 1-year TWL failure, and provide characteristics of surgery type subgroups. Finally, we provide a multivariate logistic regression model of 1-year TWL failure.

results58.8% and 45.7% of patients reported maternal and paternal predisposition for obesity, respectively. Average onset of obesity was 15.5 years and duration of disease 28.3 years prior to MBS. SG is the most frequently performed procedure (47.2%) followed by RYGB (39.7%) and OAGB (13.1%). Mean 1-year TWL is 32.7 ± 9.3%, and 7.8% (n = 1,119) of patients show TWL failure (< 20%). Multivariate analysis shows independent association of early onset of obesity (< 18 years), male sex, age at operation, pre-operative BMI, pre-operative weight loss, sleeve gastrectomy (SG), and type 2 diabetes (T2D) with 1-year TWL failure (p < 0.001).

conclusionThe proportions of MBS patients that report on paternal and maternal predisposition for obesity are 45.7% and 58.8% respectively, and average age at onset is 15.5 years. 7.8% of patients do not meet current target criteria of successful response to surgery at 1 year. Early onset, male sex, age at operation, pre-operative BMI, pre-operative weight loss, SG, and T2D are independently associated with weight loss failure.

Indexed as

Bariatric SurgeryDiabetes Mellitus, Type 2Gastric BypassObesity, MorbidAdolescentAge of OnsetCohort StudiesGastrectomyHumansMaleObesityParentsRetrospective StudiesTreatment OutcomeWeight LossBariatric and metabolic surgeryFamilial predispositionOnset of obesitySurgical weight loss failure

Identifiers

PMID36856989
PMCPMC10156869

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.