Evidence map›Paper›PMID 36858108›Full record

ArticleChemico-biological interactions2023

Cnr1

Brittany N Szafran, James Nichols, Ashleigh Nicaise, Abdolsamad Borazjani, Russell L Carr, Juliet R Wilson, Matthew K Ross, Barbara L F Kaplan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemico-biological interactions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Effect of chlorpyrifos on VEGF gene expression.Chemico-biological interactions · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Brittany N SzafranCenter for Environmental Health Sciences, Department of Comparative Biomedical Sciences, Mississippi State University, College of Veterinary Medicine, Mississippi State, MS, USA.
James NicholsCenter for Environmental Health Sciences, Department of Comparative Biomedical Sciences, Mississippi State University, College of Veterinary Medicine, Mississippi State, MS, USA.
Ashleigh NicaiseCenter for Environmental Health Sciences, Department of Comparative Biomedical Sciences, Mississippi State University, College of Veterinary Medicine, Mississippi State, MS, USA.
Abdolsamad BorazjaniCenter for Environmental Health Sciences, Department of Comparative Biomedical Sciences, Mississippi State University, College of Veterinary Medicine, Mississippi State, MS, USA.
Russell L CarrCenter for Environmental Health Sciences, Department of Comparative Biomedical Sciences, Mississippi State University, College of Veterinary Medicine, Mississippi State, MS, USA.
Juliet R WilsonCenter for Environmental Health Sciences, Department of Comparative Biomedical Sciences, Mississippi State University, College of Veterinary Medicine, Mississippi State, MS, USA.
Matthew K RossCenter for Environmental Health Sciences, Department of Comparative Biomedical Sciences, Mississippi State University, College of Veterinary Medicine, Mississippi State, MS, USA.
Barbara L F KaplanCenter for Environmental Health Sciences, Department of Comparative Biomedical Sciences, Mississippi State University, College of Veterinary Medicine, Mississippi State, MS, USA. Electronic address: bkaplan@cvm.msstate.edu.
Mississippi State University · US

Funding

Role of Carboxylesterases in Innate ImmunityR15GM128206 · NIGMS · MISSISSIPPI STATE UNIVERSITY · PI ROSS, MATTHEW K · 2018 to 2018
$421k
NIGMS NIH HHS R15 GM128206
6 · The paper itself

Abstract

Chlorpyrifos (CPF) is an organophosphate pesticide that can inhibit endocannabinoid (eCB) metabolizing enzymes in animal models at levels that do not significantly alter acetylcholinesterase (AChE) in the central nervous system (CNS). Previous studies indicated that repeated low-level CPF exposure in developing rats increased the levels of eCBs in the brain. Because eCBs play a role in immune homeostasis through their engagement with cannabinoid receptors, we investigated the role of cannabinoid receptor 1 (CB1, encoded by the Cnr1 gene) on the CPF-mediated effects in the spleen and lung of neonatal and adult female mice. We treated neonatal and adult female Cnr1

Indexed as

ChlorpyrifosInsecticidesAcetylcholinesteraseAnimalsCholinesterase InhibitorsCytokinesEndocannabinoidsFemaleLipopolysaccharidesMiceReceptor, Cannabinoid, CB1SpleenAcetylcholinesteraseChlorpyrifosCholinesterase InhibitorsCNR1 protein, mouseCnr1 protein, ratCytokinesEndocannabinoidsInsecticidesLipopolysaccharidesReceptor, Cannabinoid, CB1Cannabinoid receptor 1ChlorpyrifosEndocannabinoidsOrganophosphates

Identifiers

PMID36858108
PMCPMC10150269
OpenAlexW4322489609

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.