Evidence map›Paper›PMID 36863713›Full record

ArticleAging2023

Ginkgolide A improves the pleiotropic function and reinforces the neuroprotective effects by mesenchymal stem cell-derived exosomes in 6-OHDA-induced cell model of Parkinson's disease.

William Shao-Tsu Chen, Tzu-Ying Lin, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Wei-Wen Kuo, Shih-Chieh Liao, Hui-Chuan Kao, Da-Tong Ju, Yu-Jung Lin, Chih-Yang Huang

Open access · hybridFull text read
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  9. Antioxidants (Basel, Switzerland) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

William Shao-Tsu ChenDepartment of Psychiatry, Tzu Chi General Hospital, Hualien 97004, Taiwan.
Tzu-Ying LinCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Dennis Jine-Yuan HsiehClinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Wei-Wen KuoDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Shih-Chieh LiaoGraduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan.
Hui-Chuan KaoDepartment of Public Health, Tzu Chi University, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Da-Tong JuDepartment of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yu-Jung LinCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
Chih-Yang HuangCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan.
China Medical University · TWTzu Chi Foundation · TWTzu Chi University · TWChina Medical University Hospital · TWChung Shan Medical University · TWTri-Service General Hospital · TWUniversity of Taipei · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a common disorder attributed to the loss of midbrain dopamine (mDA) neurons and reduced dopamine secretion. Currently, the treatment regimes for PD comprise deep brain stimulations, however, it attenuates the PD progression marginally and does not improve neuronal cell death. We investigated the function of Ginkgolide A (GA) to reinforce Wharton's Jelly-derived mesenchymal stem cells (WJMSCs) for treating the

Indexed as

ExosomesMesenchymal Stem CellsNeuroprotective AgentsParkinson Diseasealpha-SynucleinDopamineGinkgolidesHumansLactonesOxidopaminealpha-SynucleinDopamineginkgolide AGinkgolidesLactonesNeuroprotective AgentsOxidopamine6-hydroxydopamineexosomesGinkgolide Amesenchymal stem cellparkinson’s diseaseWharton’s jelly

Identifiers

PMID36863713
PMCPMC10042680
OpenAlexW4322764467

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read28
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.