Evidence map›Paper›PMID 36864256›Full record

SynthesisJournal of neurology2023

The effect of exercise on cognitive function in people with multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.

Gen Li, Qiuping You, Xiao Hou, Shiyan Zhang, Liwen Du, Yuanyuan Lv, Laikang Yu

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gen Li *Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China.
Qiuping You *Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China.
Xiao HouSchool of Sport Sciences, Beijing Sport University, Beijing, China.
Shiyan ZhangDepartment of Sports Performance, Beijing Sport University, Beijing, China.
Liwen DuDepartment of Sports Performance, Beijing Sport University, Beijing, China.
Yuanyuan LvKey Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China. sunflowerlyy@bsu.edu.cn.ORCID http://orcid.org/0000-0002-4397-8768
Laikang YuKey Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China. yulaikang@126.com.ORCID http://orcid.org/0000-0001-7649-5095

Funding

Chinese Universities Scientific Fund 2022QN015National Key R&D Program of China 2022YFC3600201
6 · The paper itself

Abstract

objectiveA growing body of research examining the effect of exercise on cognitive function in people with multiple sclerosis (MS), while findings of available studies were conflicting. We aimed to explore the effect of exercise on cognitive function in MS patients.

methodsFor this systematic review and meta-analysis, we searched PubMed, Web of Science, EBSCO, Cochrane, and Scopus electronic databases, through July 18, 2022. Cochrane risk assessment tool was used to evaluate the methodological quality of the included literature.

resultsTwenty-one studies with a total of 23 experimental groups and 21 control groups met the inclusion criteria. There was a significant effect of exercise on improving cognitive function in MS patients, while the effect size was small (Cohen's d = 0.20, 95% CI 0.06-0.34, p < 0.001, I

conclusionMS patients are recommended to participate in at least three multicomponent training sessions per week, with each session lasting up to 60 min, and the exercise goal of 180 min per week can be achieved by increasing the frequency of exercise. Exercise lasting 8 or 10 weeks is best for cognitive function improvement. Additionally, a worse basal MS status, or the older the age, the greater effect on cognitive function.

Indexed as

Multiple SclerosisCognitionExerciseExercise TherapyHumansRandomized Controlled Trials as TopicCognitive functionExerciseMeta-analysisMultiple sclerosisSystematic review

Identifiers

PMID36864256

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.