Evidence map›Paper›PMID 36864286›Full record

SynthesisJournal of human genetics2023

Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations.

Mohanraj Krishnan, Amanda Phipps-Green, Emily M Russell, Tanya J Major, Murray Cadzow, Lisa K Stamp, Nicola Dalbeth, Jennie Harré Hindmarsh, Muhammad Qasim, Huti Watson and 11 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of human genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 3 countries.

Mohanraj KrishnanDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Amanda Phipps-GreenDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Emily M RussellDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Tanya J MajorDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0002-1955-0219
Murray CadzowDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.
Lisa K StampDepartment of Medicine, University of Otago, Christchurch, New Zealand.
Nicola DalbethDepartment of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0003-4632-4476
Jennie Harré HindmarshNgāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand.
Muhammad QasimNgāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand.
Huti WatsonNgāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand.
Shuwei LiuDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Jenna C CarlsonDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-5483-0833
Ryan L MinsterDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Nicola L HawleyDepartment of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2601-3454
Take NaseriMinistry of Health, Government of Samoa, Apia, Samoa.
Muagututi'a Sefuiva ReupenaLutia i Puava ae Mapu i Fagalele, Apia, Samoa.
Ranjan DekaDepartment of Environmental and Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Stephen T McGarveyInternational Health Institute, Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0003-1233-6970
Tony R MerrimanDepartment of Biochemistry, University of Otago, Dunedin, New Zealand.ORCID http://orcid.org/0000-0003-0844-8726
Rinki MurphyDepartment of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-0043-2423
Daniel E WeeksDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. weeks@pitt.edu.ORCID http://orcid.org/0000-0001-9410-7228
University of Pittsburgh · USUniversity of Otago · NZNational University of Samoa · WSUniversity of Auckland · NZBrown University · USUniversity of Cincinnati Medical Center · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Integrated cellular, mouse and human research on a novel missense variant influencing adiposity in SamoansR01HL093093 · NHLBI · BROWN UNIVERSITY · PI MCGARVEY, STEPHEN T. · 2009 to 2019
$8.2M
Next Generation Association Studies of Adiposity in Samoans Enhanced by a Samoan-Specific Whole Genome Sequence Reference PanelR01HL133040 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ryan Lee Minster · 2017 to 2026
$7.5M
GENOME SCAN FOR OBESITY SUSCEPTIBILITY LOCI IN SAMOANSR01DK059642 · NIDDK · BROWN UNIVERSITY · PI MCGARVEY, STEPHEN T. · 2000 to 2004
$2.6M
GENOME SCAN FOR NIDDM SUSCEPTIBILITY GENES AMONG SAMOANSR01DK055406 · NIDDK · UNIVERSITY OF CINCINNATI · PI DEKA, RANJAN · 1998 to 2002
$664k
GENETICS OF CVD RISK FACTORS IN SAMOANSR01HL052611 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1995 to 1998
–
ADIPOSITY INSULIN ELECTROLYTES AND SAMOAN BLOOD PRESSURER01AG009375 · NIA · MIRIAM HOSPITAL · PI MCGARVEY, STEPHEN T. · 1990 to 1994
–
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL052611NHLBI NIH HHS R01 HL093093NHLBI NIH HHS R01 HL133040NIA NIH HHS R01 AG009375NIDDK NIH HHS R01 DK055406NIDDK NIH HHS R01 DK059642NIEHS NIH HHS P30 ES006096
6 · The paper itself

Abstract

The fat mass and obesity associated (FTO) locus consistently associates with higher body mass index (BMI) across diverse ancestral groups. However, previous small studies of people of Polynesian ancestries have failed to replicate the association. In this study, we used Bayesian meta-analysis to test rs9939609, the most replicated FTO variant, for association with BMI with a large sample (n = 6095) of Aotearoa New Zealanders of Polynesian (Māori and Pacific) ancestry and of Samoan people living in the Independent State of Samoa and in American Samoa. We did not observe statistically significant association within each separate Polynesian subgroup. Bayesian meta-analysis of the Aotearoa New Zealand Polynesian and Samoan samples resulted in a posterior mean effect size estimate of +0.21 kg/m

Indexed as

Body Mass IndexMaori PeoplePacific Island PeopleAlpha-Ketoglutarate-Dependent Dioxygenase FTOBayes TheoremGenetic Predisposition to DiseaseHumansNew ZealandPolymorphism, Single NucleotideAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, human

Identifiers

PMID36864286
PMCPMC10313811
OpenAlexW4322771629

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.