Evidence map›Paper›PMID 36864883›Full record

ArticleFrontiers in cellular and infection microbiology2023

Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes.

Zandile Nare, Tessa Moses, Karl Burgess, Achim Schnaufer, Malcolm D Walkinshaw, Paul A M Michels

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zandile NareInstitute of Immunology and Infection Research, School of Biological Sciences, Ashworth Building, The University of Edinburgh, Edinburgh, United Kingdom.
Tessa MosesEdinOmics, RRID:SCR_021838, Centre for Engineering Biology, School of Biological Sciences, CH Waddington Building, The University of Edinburgh, Edinburgh, United Kingdom.
Karl BurgessEdinOmics, RRID:SCR_021838, Centre for Engineering Biology, School of Biological Sciences, CH Waddington Building, The University of Edinburgh, Edinburgh, United Kingdom.
Achim SchnauferInstitute of Immunology and Infection Research, School of Biological Sciences, Ashworth Building, The University of Edinburgh, Edinburgh, United Kingdom.
Malcolm D WalkinshawWellcome Centre for Cell Biology, School of Biological Sciences, Michael Swann Building, The University of Edinburgh, Edinburgh, United Kingdom.
Paul A M MichelsWellcome Centre for Cell Biology, School of Biological Sciences, Michael Swann Building, The University of Edinburgh, Edinburgh, United Kingdom.
University of Edinburgh · GB

Funding

Biotechnology and Biological Sciences Research CouncilWellcome Trust
6 · The paper itself

Abstract

Previously, we reported the development of novel small molecules that are potent inhibitors of the glycolytic enzyme phosphofructokinase (PFK) of

Indexed as

PhosphofructokinasesTrypanosomaAdenosine TriphosphateAnimalsHumansMetabolomeMetabolomicsAdenosine TriphosphatePhosphofructokinasesATP productioncarnitine/acylcarnitine translocationglycolytic metabolitesmetabolomicsmode of inhibitionphosphofructokinaseTrypanosoma

Identifiers

PMID36864883
PMCPMC9971811
OpenAlexW4320723529

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.