Evidence map›Paper›PMID 36865196›Full record

ArticlebioRxiv : the preprint server for biology2023

O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations.

Duc T Huynh, Jimin Hu, Jordan R Schneider, Kalina N Tsolova, Erik J Soderblom, Abigail J Watson, Jen-Tsan Chi, Chantell S Evans, Michael Boyce

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Duc T HuynhDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Jimin HuDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Jordan R SchneiderDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Kalina N TsolovaDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Erik J SoderblomProteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC 27710, USA.
Abigail J WatsonDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Jen-Tsan ChiDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Chantell S EvansDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Michael BoyceDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Duke University · US

Funding

Research Education Component CoreP30AG072958 · NIA · DUKE UNIVERSITY · PI Heather E. Whitson · 2021 to 2026
$24.1M
Cell signaling through O-GlcNAc reader proteinsR01GM118847 · NIGMS · DUKE UNIVERSITY · PI BOYCE, MICHAEL S · 2016 to 2025
$2.8M
Metabolic regulation of KLHL proteins through O-glycosylationR01NS111588 · NINDS · DUKE UNIVERSITY · PI BOYCE, MICHAEL S, CHI, JEN-TSAN ASHLEY · 2019 to 2022
$2.1M
UCSD Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Faculty Development ProgramR25NS117367 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Victoria B Risbrough, Joann Trejo · 2020 to 2026
$1.6M
NIA NIH HHS P30 AG072958NIGMS NIH HHS R01 GM118847NINDS NIH HHS R01 NS111588NINDS NIH HHS R25 NS117367
6 · The paper itself

Abstract

The neurofilament (NF) cytoskeleton is critical for neuronal morphology and function. In particular, the neurofilament-light (NF-L) subunit is required for NF assembly

Identifiers

PMID36865196
PMCPMC9980138
OpenAlexW4321482821

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.