Evidence map›Paper›PMID 36865271›Full record

ArticlebioRxiv : the preprint server for biology2023

Arsenic is a potent co-mutagen of ultraviolet light.

Rachel M Speer, Shuvro P Nandi, Karen L Cooper, Xixi Zhou, Hui Yu, Yan Guo, Laurie G Hudson, Ludmil B Alexandrov, Ke Jian Liu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rachel M SpeerDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA.
Shuvro P NandiDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, 92093, USA.
Karen L CooperDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA.
Xixi ZhouDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA.
Hui YuDepartment of Internal Medicine, Division of Molecular Medicine, University of New Mexico, Albuquerque, NM 87106, USA.
Yan GuoDepartment of Internal Medicine, Division of Molecular Medicine, University of New Mexico, Albuquerque, NM 87106, USA.
Laurie G HudsonDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, 92093, USA.
Ke Jian LiuDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA.
University of New Mexico · USUniversity of California San Diego · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
University of New Mexico Center for Metals in Biology and Medicine - equipment supplementP20GM130422 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Matthew J Campen · 2020 to 2026
$20.4M
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4M
Mutational Signatures of a Combined Environmental Exposure: Arsenic and Ultraviolet RadiationR01ES030993 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI HUDSON, LAURIE G, LIU, KE JIAN · 2020 to 2024
$2.5M
Comprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2M
NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA269919NIEHS NIH HHS R01 ES030993NIEHS NIH HHS R01 ES032547NIGMS NIH HHS P20 GM130422
6 · The paper itself

Abstract

Environmental co-exposures are widespread and are major contributors to carcinogenic mechanisms. Two well-established environmental agents causing skin cancer are ultraviolet radiation (UVR) and arsenic. Arsenic is a known co-carcinogen that enhances UVR's carcinogenicity. However, the mechanisms of arsenic co-carcinogenesis are not well understood. In this study, we utilized primary human keratinocytes and a hairless mouse model to investigate the carcinogenic and mutagenic properties of co-exposure to arsenic and UVR.

Identifiers

PMID36865271
PMCPMC9980120
OpenAlexW4321607211

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.