Evidence map›Paper›PMID 36865293›Full record

ArticlebioRxiv : the preprint server for biology2023

Tenascin-C activation of lung fibroblasts in a 3D synthetic lung extracellular matrix mimic.

Aritra Nath Kundu, Carey E Dougan, Samar Mahmoud, Alara Kilic, Alexi Panagiotou, Ninette Irakoze, Nathan Richbourg, Shelly R Peyton

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aritra Nath KunduDepartment of Chemical Engineering, University of Massachusetts Amherst.
Carey E DouganDepartment of Chemical Engineering, University of Massachusetts Amherst.
Samar MahmoudMolecular and Cellular Biology Graduate Program, University of Massachusetts Amherst.
Alara KilicDepartment of Biochemistry and Molecular Biology, University of Massachusetts Amherst.
Alexi PanagiotouMolecular and Cellular Biology Graduate Program, University of Massachusetts Amherst.
Ninette IrakozeDepartment of Chemical Engineering, University of Massachusetts Amherst.
Nathan RichbourgDepartment of Chemical Engineering, University of Massachusetts Amherst.
Shelly R PeytonDepartment of Chemical Engineering, University of Massachusetts Amherst.
University of Massachusetts Amherst · US

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Biotechnology Training Program in Applied Life SciencesT32GM135096 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jeanne Ann Hardy, Ashish A. Kulkarni · 2020 to 2026
$3.9M
Tissue-specific stem cells and breast cancer tissue tropism in bioengineered microenvironmentsDP2CA186573 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI PEYTON, SHELLY R. · 2013 to 2015
$2.6M
Acquisition of an Orbitrap MSS10OD010645 · OD · UNIVERSITY OF MASSACHUSETTS AMHERST · PI EYLES, STEPHEN J. · 2013 to 2013
$600k
NCI NIH HHS DP2 CA186573NIGMS NIH HHS T32 GM008515NIGMS NIH HHS T32 GM135096NIH HHS S10 OD010645
6 · The paper itself

Abstract

The lung extracellular matrix (ECM) maintains the structural integrity of the tissue and regulates the phenotype and functions of resident fibroblasts. Lung-metastatic breast cancer alters these cell-ECM interactions, promoting fibroblast activation. There is a need for bio-instructive ECM models that contain the ECM composition and biomechanics of the lung to study these cell-matrix interactions

Identifiers

PMID36865293
PMCPMC9980292
OpenAlexW4322008791

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.