ArticleThe EPMA journal2023
Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects.
Article in The EPMA journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04037384 (Alternative Home Training Possibilities for Glaucoma Patients), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Alternative Home Training Possibilities for Glaucoma Patients
Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Advancing Retinal Vessel Analysis: Reproducibility of Myogenic Constriction and Assessment of Regulatory Capacity.Translational vision science & technology · 2026Article
- Vision restoration in glaucoma: improved subjective visual function after personalised digital lifestyle coaching.The EPMA journal · 2026Article
- Age-Related Neurovascular Dysfunction in the Retina and Potential Pathogenic Mechanisms.Investigative ophthalmology & visual science · 2026Review
- Association Between Intraocular Pressure Changes and Optic Nerve Head and Macular Perfusion Parameters During Isometric Exercise: OCTA Study.Diagnostics (Basel, Switzerland) · 2026Article
- Investigating neurovascular responses of the peripapillary retinal artery to focal flicker stimulation of temporal retinal neurons in the living human eye using AO-OCT.Biomedical optics express · 2026Article
- Research progress on molecular therapy for glaucoma (Review).Molecular medicine reports · 2026Review
- Impact of Aging and Light Stimulation Parameters on Retinal Hyperemia Responses in Functional Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2025Article
- Retinal Vessel Diameter Reductions Are Associated with Retinal Ganglion Cell Dysfunction, Thinning of the Ganglion Cell and Inner Plexiform Layers, and Decreased Visual Field Global Indices in Glaucoma Suspects.Diagnostics (Basel, Switzerland) · 2025Article
- Comprehensive genome-wide analysis of retinal vessel caliber reveals microvascular-blood pressure pathways: advancing predictive, preventive, and personalized medicine.The EPMA journal · 2025Article
- Correlation of optic nerve hemoglobin levels with structural and functional parameters in glaucoma.Scientific reports · 2025Article
- Associations Between Cerebral Perfusion Pressure, Hemodynamic Parameters, and Cognitive Test Values in Normal-Tension Glaucoma Patients, Alzheimer's Disease Patients, and Healthy Controls.Medicina (Kaunas, Lithuania) · 2025Article
- Eye yoga for glaucoma: recovery of vascular dysregulation and visual field function-a randomized controlled trial.The EPMA journal · 2025Article
- Characterising the Time Course of the Dilatory Response of Healthy Retinal Arteries during Flicker-Light Provocation.Journal of vascular research · 2025Article
- Genetic association of lipid traits and lipid-related drug targets with normal tension glaucoma: a Mendelian randomization study for predictive preventive and personalized medicine.The EPMA journal · 2024Article
- Integrative neurovascular coupling and neurotransmitter analyses in anisometropic and visual deprivation amblyopia children.iScience · 2024Article
- [Glaucoma Patient with Suspected Flammer Syndrome: Diagnostic Procedures and Therapeutic Implications].Klinische Monatsblatter fur Augenheilkunde · 2024Review
- The Association between Vascular Abnormalities and Glaucoma-What Comes First?International journal of molecular sciences · 2023Review
- Analysis of retinal arteriolar and venular parameters in primary open angle glaucoma.International journal of ophthalmology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Vision loss in glaucoma is not only associated with elevated intraocular pressure and neurodegeneration, but vascular dysregulation (VD) is a major factor. To optimize therapy, an improved understanding of concepts of predictive, preventive, and personalized medicine (3PM) is needed which is based on a more detailed understanding of VD pathology. Specifically, to learn if the root cause of glaucomatous vision loss is of neuronal (degeneration) or vascular origin, we now studied neurovascular coupling (NVC) and vessel morphology and their relationship to vision loss in glaucoma. Methods: In patients with primary open angle glaucoma (POAG) ( Results: Retinal arterial and venous vessels had significantly smaller diameters in patients with POAG in comparison to controls. However, both arterial and venous dilation reached normal values during neuronal activation despite their smaller diameters. This was largely independent of visual field depth and varied among patients. Conclusions: Because dilation/constriction is normal, VD in POAG can be explained by chronic vasoconstriction which limits energy supply to retinal (and brain) neurons with subsequent hypo-metabolism ("silent" neurons) or neuronal cell death. We propose that the root cause of POAG is primarily of vascular and not neuronal origin. This understanding can help to better personalize POAG therapy of not only targeting eye pressure but also vasoconstriction to prevent low vision, slowing its progression and supporting recovery and restoration. Trial registration: ClinicalTrials.gov, # NCT04037384 on July 3, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.