ArticleToxicology research2023
Glutathione attenuated lambda-cyhalothrin-induced alteration of serum total cholesterol concentration and oxidative stress parameters in rats.
Article in Toxicology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors at 1 institution in 1 country.
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Abstract
Background: Lambda-cyhalothrin is a type II pyrethroid insecticide that is used for pest control in agricultural, domestic, and industrial settings. Glutathione is an antioxidant that has been reported to confer protection on biological systems against the adverse impacts of insecticides. Objective: The aim of the study was to evaluate the effects of glutathione on the serum lipid profile and oxidative stress parameters of rats exposed to lambda-cyhalothrin toxicity. Methods: Thirty-five rats were assigned into 5 groups each. Distilled water was given to the first group, whereas the second group received soya oil (1 mL/kg). Lambda-cyhalothrin (25 mg/kg) was administered to the third group. The fourth group was given lambda-cyhalothrin (25 mg/kg) and glutathione (100 mg/kg) successively, whereas the fifth group received lambda-cyhalothrin (25 mg/kg) and glutathione (200 mg/kg) consecutively. The treatments were administered once daily by oral gavage for 21 days. The rats were sacrificed after the completion of the study. The serum lipid profile and oxidative stress parameters were assessed. Results: A significant ( Conclusion: The advantageous effects of glutathione may be ascribed to its antioxidant property.
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