Evidence map›Paper›PMID 36866247›Full record

ArticleiScience2023

PIMT regulates hepatic gluconeogenesis in mice.

Bandish Kapadia, Soma Behera, Sireesh T Kumar, Tapan Shah, Rebecca Kristina Edwin, Phanithi Prakash Babu, Partha Chakrabarti, Kishore V L Parsa, Parimal Misra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Bandish KapadiaCenter for Innovation in Molecular and Pharmaceutical Sciences, Dr. Reddy's Institute of Life Sciences (DRILS), University of Hyderabad Campus, Hyderabad, TG 500046, India.
Soma BeheraCenter for Innovation in Molecular and Pharmaceutical Sciences, Dr. Reddy's Institute of Life Sciences (DRILS), University of Hyderabad Campus, Hyderabad, TG 500046, India.
Sireesh T KumarDepartment of Biotechnology, University of Hyderabad, Hyderabad 500046, India.
Tapan ShahDepartment of Biochemistry, Saurashtra University, Rajkot 360005, India.
Rebecca Kristina EdwinCenter for Innovation in Molecular and Pharmaceutical Sciences, Dr. Reddy's Institute of Life Sciences (DRILS), University of Hyderabad Campus, Hyderabad, TG 500046, India.
Phanithi Prakash BabuDepartment of Biotechnology, University of Hyderabad, Hyderabad 500046, India.
Partha ChakrabartiIndian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India.
Kishore V L ParsaCenter for Innovation in Molecular and Pharmaceutical Sciences, Dr. Reddy's Institute of Life Sciences (DRILS), University of Hyderabad Campus, Hyderabad, TG 500046, India.
Parimal MisraCenter for Innovation in Molecular and Pharmaceutical Sciences, Dr. Reddy's Institute of Life Sciences (DRILS), University of Hyderabad Campus, Hyderabad, TG 500046, India.
University of Hyderabad · INInstitute of Life Sciences · INIndian Institute of Chemical Biology · INSaurashtra University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The physiological and metabolic functions of PIMT/TGS1, a third-generation transcriptional apparatus protein, in glucose homeostasis sustenance are unclear. Here, we observed that the expression of PIMT was upregulated in the livers of short-term fasted and obese mice. Lentiviruses expressing Tgs1-specific shRNA or cDNA were injected into wild-type mice. Gene expression, hepatic glucose output, glucose tolerance, and insulin sensitivity were evaluated in mice and primary hepatocytes. Genetic modulation of PIMT exerted a direct positive impact on the gluconeogenic gene expression program and hepatic glucose output. Molecular studies utilizing cultured cells,

Indexed as

HepatologyHuman metabolismMolecular biology

Identifiers

PMID36866247
PMCPMC9972567
OpenAlexW4318953565

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.