Evidence map›Paper›PMID 36866682›Full record

ReviewUnited European gastroenterology journal2023

Influence of sex in alcohol-related liver disease: Pre-clinical and clinical settings.

Debora Bizzaro, Chiara Becchetti, Silvia Trapani, Bruna Lavezzo, Alberto Zanetto, Francesca D'Arcangelo, Manuela Merli, Lucia Lapenna, Federica Invernizzi, Gloria Taliani and 2 more

Open access · hybridAbstract readReview
In one paragraph

Review in United European gastroenterology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 52 citations in OpenAlex.

  1. Time-Varying Impact of Steatosis and Alcohol on Mortality: A Marginal Structural Model of the Canadian Longitudinal Study on Aging.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Women and alcohol: A call to action.Alcohol, clinical & experimental research · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Debora BizzaroDepartment of Surgery, Oncology, and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padua University Hospital, Padua, Italy.
Chiara BecchettiHepatology and Gastroenterology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Silvia TrapaniItalian National Transplant Center, National Institute of Health, Rome, Italy.
Bruna LavezzoAnesthesia and Intensive Care Unit 2, Liver Transplant Center, A.O.U. Città della Salute e della Scienza, Turin, Italy.
Alberto ZanettoDepartment of Surgery, Oncology, and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padua University Hospital, Padua, Italy.ORCID 0000-0002-6734-7178
Francesca D'ArcangeloDepartment of Surgery, Oncology, and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padua University Hospital, Padua, Italy.
Manuela MerliDepartment of Translational and Precision Medicine, Centre for the Diagnosis and Treatment of Portal Hypertension, 'Sapienza' University of Rome, Rome, Italy.
Lucia LapennaDepartment of Translational and Precision Medicine, Centre for the Diagnosis and Treatment of Portal Hypertension, 'Sapienza' University of Rome, Rome, Italy.
Federica InvernizziDivision of Internal Medicine and Hepatology, Center for Liver Disease, IRCCS Ospedale San Raffaele, Milan, Italy.
Gloria TalianiDepartment of Public Health and Infectious Diseases, Infectious and Tropical Medicine Unit, 'Policlinico Umberto I' Hospital, Sapienza University of Rome, Rome, Italy.
Patrizia BurraDepartment of Surgery, Oncology, and Gastroenterology, Gastroenterology and Multivisceral Transplant Unit, Padua University Hospital, Padua, Italy.ORCID 0000-0002-8791-191X
AISF Special Interest Group on Gender in Hepatology
University of Padua · ITSapienza University of Rome · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITIRCCS Ospedale San Raffaele · ITNational Institute of Health · AMPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alcohol-related liver disease (ArLD) is a major cause of chronic liver disease globally. Traditionally, ArLD was mostly a concern in men rather than in women; however, such a sex gap is rapidly narrowing due to increasing chronic alcohol consumption among women. Female sex is more vulnerable to the harmful effects of alcohol with a higher risk of progression to cirrhosis and development of associated complications. The relative risk of cirrhosis and liver-related mortality is significantly higher in women than in men. Our review endeavors to summarize the current knowledge on sex differences in alcohol metabolism, pathogenesis of ArLD, disease progression, indication for liver transplant and pharmacological treatments of ArLD, and provide evidence in support of a sex-specific management of these patients.

Indexed as

Liver DiseasesLiver TransplantationEthanolFemaleHumansLiver CirrhosisMaleRiskEthanolalcoholcirrhosisgenderportal hypertensionsex

Identifiers

PMID36866682
PMCPMC10039798
OpenAlexW4323035705

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.