Evidence map›Paper›PMID 36867305›Full record

ReviewFunctional & integrative genomics2023

Ancestry, diversity, and genetics of health-related traits in African-derived communities (quilombos) from Brazil.

Iriel A Joerin-Luque, Natalie Mary Sukow, Isabela Dall'Oglio Bucco, Joana Gehlen Tessaro, Claudemira Vieira Gusmão Lopes, Ana Angélica Leal Barbosa, Marcia H Beltrame

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Functional & integrative genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. First Report of Seropositivity toJournal of parasitology research · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Iriel A Joerin-LuquePrograma de Pós-Graduação Em Genética, Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal Do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil. irieljoerin@gmail.com.ORCID http://orcid.org/0000-0003-3683-5547
Natalie Mary SukowPrograma de Pós-Graduação Em Genética, Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal Do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil.ORCID http://orcid.org/0000-0003-4270-6696
Isabela Dall'Oglio BuccoLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal Do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil.ORCID http://orcid.org/0000-0003-4565-4836
Joana Gehlen TessaroLaboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal Do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil.ORCID http://orcid.org/0000-0002-8797-112X
Claudemira Vieira Gusmão LopesCâmara de Educação Do Campo, Universidade Federal Do Paraná (UFPR), Setor Litoral, Matinhos, Paraná, 83260-000, Brazil.ORCID http://orcid.org/0000-0001-5710-5434
Ana Angélica Leal BarbosaLaboratório de Biologia E Genética Humana, Departamento de Ciências Biológicas, Universidade Estadual Do Sudoeste da Bahia (UESB), Campus de Jequié, Bahia, Brazil.ORCID http://orcid.org/0000-0002-0370-202X
Marcia H BeltramePrograma de Pós-Graduação Em Genética, Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal Do Paraná (UFPR), Centro Politécnico, Jardim das Américas, Curitiba, Paraná, 81531-980, Brazil.ORCID http://orcid.org/0000-0003-2102-6667

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 40001016006P1
6 · The paper itself

Abstract

Brazilian quilombos are communities formed by enslaved Africans and their descendants all over the country during slavery and shortly after its abolition. Quilombos harbor a great fraction of the largely unknown genetic diversity of the African diaspora in Brazil. Thus, genetic studies in quilombos have the potential to provide important insights not only into the African roots of the Brazilian population but also into the genetic bases of complex traits and human adaptation to diverse environments. This review summarizes the main results of genetic studies performed on quilombos so far. Here, we analyzed the patterns of African, Amerindian, European, and subcontinental ancestry (within Africa) of quilombos from the five different geographic regions of Brazil. In addition, uniparental markers (from the mtDNA and the Y chromosome) studies are analyzed together to reveal demographic processes and sex-biased admixture that occurred during the formation of these unique populations. Lastly, the prevalence of known malaria-adaptive African mutations and other African-specific variants discovered in quilombos, as well as the genetic bases of health-related traits, are discussed here, together with their implication for the health of populations of African descent.

Indexed as

AcclimatizationAfrican PeopleHealth StatusBrazilDNA, MitochondrialHumansMitochondriaDNA, MitochondrialBlack BraziliansComplex diseaseG6PDGenetic ancestryHemoglobinopathiesSex bias

Identifiers

PMID36867305
PMCPMC9982798

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.