ReviewPharmacological research2023
Nicotine on the developing brain.
Review in Pharmacological research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Impact of prenatal tobacco exposure on brain structure and function in offspring: a systematic review and meta-analysis of MRI findings.Neuroradiology · 2025Pooled it
- Nicotine Exposure During Gestation: From Placental Dysfunction to Long-Term Neurobehavioral Outcomes.Birth defects research · 2026Review
- Oral nicotine pouch continuity programmes and US college students' intention to use.Tobacco control · 2026Article
- Prednisone Exposure During Pregnancy Increases Susceptibility to Epilepsy in Adult Offspring Mice.Neurochemical research · 2026Article
- Neuropharmacology of Nicotine Addiction and Therapeutic Strategies for Smoking Cessation.Biology · 2026Review
- Early life nicotine vapor exposure increases nicotine vapor seeking in adult male rats.Psychopharmacology · 2026Article
- Why Adolescents Choose to Stop or Never Start Vaping: Evidence From South Africa.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Secondhand smoke exposure at home and its association with tobacco use among adolescents in Saudi Arabia: findings from the 2022 global youth tobacco survey.BMC public health · 2026Article
- Identifying risk profile for adolescent e-cigarette use: A sex-stratified machine learning analysis.Drug and alcohol dependence reports · 2026Article
- Perceived neighborhood disadvantage and current nicotine pouch use among U.S. youth.Drug and alcohol dependence · 2026Article
- Emerging multisystem disease mechanisms of e-cigarette vaping on human health.Toxicology reports · 2026Review
- An Exploratory Study of an fMRI Reward-Learning Paradigm in Developing Adolescents.Children (Basel, Switzerland) · 2026Article
- Emerging use of oral nicotine pouches among Canadian adolescents: Findings from the COMPASS-Quebec study.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- The Consequences of Prenatal Tobacco Exposure: A Systematic Review of Birth Outcomes and Developmental Trajectories.Cureus · 2026Review
- The Promotion of Oral Nicotine Pouches for Non-Smoking Cessation Purposes on TikTok.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Gender-Specific Associations Between Tobacco and Tobacco-Free Nicotine Use and Symptoms of Anxiety and Depression in Swedish Adolescents.Tobacco use insights · 2026Article
- Knowledge and attitudes toward e-cigarette smoking among health and non-health science students: A cross-sectional study.Tobacco prevention & cessation · 2026Article
- Association between household secondhand smoke exposure and ADHD in US children aged 4-15 years: Evidence from NHANES 1999-2004.Tobacco induced diseases · 2026Article
- Sources of electronic cigarette acquisition among school-going adolescents: A cross-sectional analysis of the 2022 National Health and Morbidity Survey - Adolescent Health Survey, Malaysia.Tobacco induced diseases · 2026Article
- E-cigarette use and associated factors among adolescents and young adults in northern Thailand: evidence from a population-based household survey.Frontiers in public health · 2026Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Developmental periods such as gestation and adolescence have enhanced plasticity leaving the brain vulnerable to harmful effects from nicotine use. Proper brain maturation and circuit organization is critical for normal physiological and behavioral outcomes. Although cigarette smoking has declined in popularity, noncombustible nicotine products are readily used. The misperceived safety of these alternatives lead to widespread use among vulnerable populations such as pregnant women and adolescents. Nicotine exposure during these sensitive developmental windows is detrimental to cardiorespiratory function, learning and memory, executive function, and reward related circuitry. In this review, we will discuss clinical and preclinical evidence of the adverse alterations in the brain and behavior following nicotine exposure. Time-dependent nicotine-induced changes in reward related brain regions and drug reward behaviors will be discussed and highlight unique sensitivities within a developmental period. We will also review long lasting effects of developmental exposure persisting into adulthood, along with permanent epigenetic changes in the genome which can be passed to future generations. Taken together, it is critical to evaluate the consequences of nicotine exposure during these vulnerable developmental windows due to its direct impact on cognition, potential trajectories for other substance use, and implicated mechanisms for the neurobiology of substance use disorders.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.