Evidence map›Paper›PMID 36873112›Full record

ArticleToxicon: X2023

A subfraction obtained from the venom of the tarantula

Luis Fernando Díaz-Peña, Torres-Ortiz Daniela, Manuel B Aguilar, Enoch Luis, Fernando Lazcano-Pérez, Roberto Arreguín-Espinosa, Arturo Hernandez-Cruz, César Ibarra-Alvarado, Alejandro García-Arredondo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicon: X, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Vasodilator activity ofToxicon: X · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Luis Fernando Díaz-PeñaPosgrado en Ciencias Químico Biológicas, Facultad de Química, Universidad Autónoma de Querétaro, Centro Universitario S/N, 76010, Querétaro, Querétaro, Mexico.
Torres-Ortiz DanielaPosgrado en Ciencias Químico Biológicas, Facultad de Química, Universidad Autónoma de Querétaro, Centro Universitario S/N, 76010, Querétaro, Querétaro, Mexico.
Manuel B AguilarLaboratorio de Neurofarmacología Marina, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, Querétaro, 76230, Mexico.
Enoch LuisCátedras CONACYT, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, 04510, Ciudad de México, Mexico.
Fernando Lazcano-PérezLaboratorio de Química de Biomacromoléculas, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
Roberto Arreguín-EspinosaLaboratorio de Química de Biomacromoléculas, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
Arturo Hernandez-CruzLaboratorio Nacional de Canalopatías, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad de México, Mexico.
César Ibarra-AlvaradoDepartamento de Investigación Química y Farmacológica de Productos Naturales, Facultad de Química, Universidad Autónoma de Querétaro, Centro Universitario S/N, 76010, Querétaro, Querétaro, Mexico.
Alejandro García-ArredondoDepartamento de Investigación Química y Farmacológica de Productos Naturales, Facultad de Química, Universidad Autónoma de Querétaro, Centro Universitario S/N, 76010, Querétaro, Querétaro, Mexico.
Universidad Nacional Autónoma de México · MXAutonomous University of Queretaro · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Venoms from tarantulas contain low molecular weight vasodilatory compounds whose biological action is conceived as part of the envenomation strategy due to its propagative effects. However, some properties of venom-induced vasodilation do not match those described by such compounds, suggesting that other toxins may cooperate with these ones to produce the observed biological effect. Owing to the distribution and function of voltage-gated ion channels in blood vessels, disulfide-rich peptides isolated from venoms of tarantulas could be conceived into potential vasodilatory compounds. However, only two peptides isolated from spider venoms have been investigated so far. This study describes for the first time a subfraction containing inhibitor cystine knot peptides, PrFr-I, obtained from the venom of the tarantula

Indexed as

ACh, acetylcholineADP, adenosine diphosphateCav, voltage-gated calcium channelDMEM, Dulbecco's modified eagle's mediumDRP, disulfide-rich peptideEC50, half maximal effective concentrationEmax, maximum effectendothelium-intact (E+), endothelium-denuded (E−)FBS, fetal bovine serumHPLC, high-performance liquid chromatographyICK, inhibitor cystine knotICK peptideIKCa, intermediate conductance calcium-activated potassium channelKv, voltage-gated potassium channelLC-MS/MS, liquid chromatography-tandem mass spectrometerL-type calcium voltage-gated calciumMALDI, matrix-assisted desorption ionizationNav, voltage-gated sodium channelPhe, phenylephrinePoecilotheria regalis, venomRat aortaRP, reverse phaseSEM, standard error of the meanSKCa, small conductance calcium-activated potassium channelSNP, sodium nitroprussideTEA, tetraethylammoniumTOF, time of flightTRP, transient receptor potentialVasodilationVh, holding-voltage

Identifiers

PMID36873112
PMCPMC9978846
OpenAlexW4321201246

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.