Targeting Sterylglucosidase A to Treat Aspergillus fumigatus Infections.
Nivea Pereira de Sa, Kalani Jayanetti, Dominick Rendina, Timothy Clement, Veronica Soares Brauer, Caroline Mota Fernandes, Iwao Ojima, Michael V Airola, Maurizio Del Poeta
Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors at 2 institutions in 1 country.
Nivea Pereira de SaDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0003-0901-6909
Kalani JayanettiDepartment of Chemistry, Stony Brook University, Stony Brook, New York, USA.
Dominick RendinaDepartment of Chemistry, Stony Brook University, Stony Brook, New York, USA.
Timothy ClementDepartment of Chemistry, Stony Brook University, Stony Brook, New York, USA.
Veronica Soares BrauerDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Caroline Mota FernandesDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.
Iwao OjimaDepartment of Chemistry, Stony Brook University, Stony Brook, New York, USA.
Michael V AirolaInstitute of Chemical Biology and Drug Discovery, Stony Brook, New York, USA.
Maurizio Del PoetaDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, USA.ORCID 0000-0001-8418-3120
Stony Brook University · USNorthport VA Medical Center · US
Funding
New antifungals targeting the synthesis of fungal sphingolipidsR01AI116420 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI Maurizio Del Poeta · 2016 to 2026
$7.6M
Lipid-mediated fungal pathogenesisR01AI125770 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI DEL POETA, MAURIZIO · 2016 to 2025
$6.2M
Structure and regulation of lipid metabolism and transportR35GM128666 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Michael Virgil Airola · 2018 to 2026
$4.0M
Sphingosine-1-phosphate and cryptococcosisR01AI136934 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI DEL POETA, MAURIZIO · 2018 to 2022
$2.5M
BLRD Research Career Scientist Award ApplicationIK6BX005386 · VA · NORTHPORT VA MEDICAL CENTER · PI DEL POETA, MAURIZIO · 2021 to 2025
Invasive fungal infections are a leading cause of death in immunocompromised patients. Current therapies have several limitations, and innovative antifungal agents are critically needed. Previously, we identified the fungus-specific enzyme sterylglucosidase as essential for pathogenesis and virulence of Cryptococcus neoformans and Aspergillus fumigatus (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Targeting Sterylglucosidase A to Treat Aspergillus fumigatus Infections. · full record | Socratic