Evidence map›Paper›PMID 36877178›Full record

ArticleACS sensors2023

Accurate Post-Calibration Predictions for Noninvasive Glucose Measurements in People Using Confocal Raman Spectroscopy.

Anders Pors, Kaspar G Rasmussen, Rune Inglev, Nina Jendrike, Amalie Philipps, Ajenthen G Ranjan, Vibe Vestergaard, Jan E Henriksen, Kirsten Nørgaard, Guido Freckmann and 3 more

Open access · hybridFull text read
In one paragraph

Article in ACS sensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 43 citations in OpenAlex.

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  10. Diabetes Technology Meeting 2023.Journal of diabetes science and technology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Anders PorsRSP Systems, Sivlandvænget 27C, 5260 Odense, Denmark.ORCID 0000-0003-0317-7592
Kaspar G RasmussenRSP Systems, Sivlandvænget 27C, 5260 Odense, Denmark.
Rune InglevRSP Systems, Sivlandvænget 27C, 5260 Odense, Denmark.
Nina JendrikeInstitute for Diabetes Technology at University of Ulm, Lise-Meitner-Straße 8/2, 89081 Ulm, Germany.
Amalie PhilippsRSP Systems, Sivlandvænget 27C, 5260 Odense, Denmark.
Ajenthen G RanjanSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark.
Vibe VestergaardSteno Diabetes Center Odense, Kløvervænget 10, 5000 Odense, Denmark.
Jan E HenriksenSteno Diabetes Center Odense, Kløvervænget 10, 5000 Odense, Denmark.
Kirsten NørgaardSteno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark.
Guido FreckmannInstitute for Diabetes Technology at University of Ulm, Lise-Meitner-Straße 8/2, 89081 Ulm, Germany.ORCID 0000-0002-0406-9529
Karl D HeppUniversity of Munich (emeritus), Geschwister-Scholl-Platz 1, 80539 Munich, Germany.
Michael C GerstenbergRSP Systems, Sivlandvænget 27C, 5260 Odense, Denmark.
Anders WeberRSP Systems, Sivlandvænget 27C, 5260 Odense, Denmark.
Steno Diabetes Centers · DKUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In diabetes prevention and care, invasiveness of glucose measurement impedes efficient therapy and hampers the identification of people at risk. Lack of calibration stability in non-invasive technology has confined the field to short-term proof of principle. Addressing this challenge, we demonstrate the first practical use of a Raman-based and portable non-invasive glucose monitoring device used for at least 15 days following calibration. In a home-based clinical study involving 160 subjects with diabetes, the largest of its kind to our knowledge, we find that the measurement accuracy is insensitive to age, sex, and skin color. A subset of subjects with type 2 diabetes highlights promising real-life results with 99.8% of measurements within A + B zones in the consensus error grid and a mean absolute relative difference of 14.3%. By overcoming the problem of calibration stability, we remove the lingering uncertainty about the practical use of non-invasive glucose monitoring, boding a new, non-invasive era in diabetes monitoring.

Indexed as

Diabetes Mellitus, Type 2Blood GlucoseBlood Glucose Self-MonitoringCalibrationHumansSpectrum Analysis, RamanBlood Glucosecalibration stabilitydiabetesin vivo Raman spectroscopymultivariate data analysisnon-invasive glucose monitoringportable sensortissue diagnostics

Identifiers

PMID36877178
PMCPMC10043934
OpenAlexW4323294205

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read39
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.