Evidence map›Paper›PMID 36879097›Full record

ArticleCommunications biology2023

A genetic locus complements resistance to Bordetella pertussis-induced histamine sensitization.

Abbas Raza, Sean A Diehl, Dimitry N Krementsov, Laure K Case, Dawei Li, Jason Kost, Robyn L Ball, Elissa J Chesler, Vivek M Philip, Rui Huang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Abbas RazaDepartment of Medicine, University of Vermont, Burlington, VT, 05405, USA.
Sean A DiehlDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, 05405, USA.
Dimitry N KrementsovDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT, 05405, USA.
Laure K CaseThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Dawei LiDepartment of Biomedical Science, Florida Atlantic University, Boca Raton, FL, 33431, USA.ORCID 0000-0002-9214-4487
Jason KostCatalytic Data Science, Charleston, SC, 29403, USA.
Robyn L BallThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Elissa J CheslerThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.ORCID 0000-0002-5642-5062
Vivek M PhilipThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Rui HuangSchool of Life Sciences, University of the Chinese Academy of Sciences, 100049, Beijing, China.
Yan ChenSchool of Life Sciences, University of the Chinese Academy of Sciences, 100049, Beijing, China.ORCID 0000-0003-4512-2821
Runlin MaSchool of Life Sciences, University of the Chinese Academy of Sciences, 100049, Beijing, China.
Anna L TylerDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT, 05405, USA.ORCID 0000-0001-8371-2377
J Matthew MahoneyThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.ORCID 0000-0003-1425-5939
Elizabeth P BlankenhornDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, 19129, USA.
Cory TeuscherDepartment of Medicine, University of Vermont, Burlington, VT, 05405, USA. c.teuscher@med.uvm.edu.ORCID 0000-0002-9236-8843
University of Vermont · USJackson Laboratory · USUniversity of Chinese Academy of Sciences · CNCatalytic Materials (United States) · USDrexel University · USFlorida Atlantic University · US

Funding

Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI MICHAEL L WHITFIELD · 2019 to 2026
$27.2M
The Jackson Laboratory Center for Precision GeneticsU54OD030187 · OD · JACKSON LABORATORY · PI Stephen A Murray · 2020 to 2026
$17.2M
Mouse Phenome ProjectR01DA028420 · NIDA · JACKSON LABORATORY · PI Elissa J Chesler · 2010 to 2026
$9.5M
Interactions Between Host Genetics and the Gut Microbiome in CNS AutoimmunityR01NS097596 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KREMENTSOV, DIMITRY N · 2017 to 2021
$1.7M
Next generation systems analysis of pathogenetic mechanisms underlying CNS autoimmunityR21AI145306 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KREMENTSOV, DIMITRY N · 2019 to 2020
$429k
Inferring Molecular Mechanisms of Complex Disease by Integrating Patterns of Epistasis with Functional Genomic NetworksR21LM012615 · NLM · JACKSON LABORATORY · PI MAHONEY, JOHN MATTHEW, TYLER, ANNA L. · 2018 to 2019
$423k
NIAID NIH HHS R21 AI145306NIDA NIH HHS R01 DA028420NIGMS NIH HHS P20 GM130454NIH HHS U54 OD030187NINDS NIH HHS R01 NS097596NLM NIH HHS R21 LM012615ODCDC CDC HHS U54 OD030187
6 · The paper itself

Abstract

Histamine plays pivotal role in normal physiology and dysregulated production of histamine or signaling through histamine receptors (HRH) can promote pathology. Previously, we showed that Bordetella pertussis or pertussis toxin can induce histamine sensitization in laboratory inbred mice and is genetically controlled by Hrh1/HRH1. HRH1 allotypes differ at three amino acid residues with P

Indexed as

Bordetella pertussisHistamineAnimalsComplement System ProteinsGenetic LociIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMicePertussis ToxinRibonucleoproteinsSignal TransductionComplement System ProteinsHistamineIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMkrn2 protein, mousePertussis ToxinPlxnd1 protein, mouseRibonucleoproteins

Identifiers

PMID36879097
PMCPMC9988836
OpenAlexW4323310980

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.