Evidence map›Paper›PMID 36879887›Full record

ArticleJHEP reports : innovation in hepatology2023

High producer variant of lipoprotein lipase may protect from hepatocellular carcinoma in alcohol-associated cirrhosis.

Franziska Schmalz, Janett Fischer, Hamish Innes, Stephan Buch, Christine Möller, Madlen Matz-Soja, Witigo von Schönfels, Benjamin Krämer, Bettina Langhans, Alexandra Klüners and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Alcohol-associated liver disease.The Journal of clinical investigation · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Franziska SchmalzDepartment of Internal Medicine I, University Hospital, University of Bonn, Germany.
Janett FischerDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Hamish InnesSchool of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK.
Stephan BuchMedical Department 1, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany.
Christine MöllerDepartment of Internal Medicine I, University Hospital, University of Bonn, Germany.
Madlen Matz-SojaDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Witigo von SchönfelsDepartment of General, Visceral-, Thoracic-, Transplantation- and Pediatric Surgery, University Medical Center Schleswig-Holstein (UKSH), Campus Kiel, and Christian-Albrecht University (CAU), Kiel, Germany.
Benjamin KrämerDepartment of Internal Medicine I, University Hospital, University of Bonn, Germany.
Bettina LanghansDepartment of Internal Medicine I, University Hospital, University of Bonn, Germany.
Alexandra KlünersDepartment of Internal Medicine I, University Hospital, University of Bonn, Germany.
Michael SoykaPsychiatric Hospital, Ludwig Maximilians University, Munich, Germany.
Felix StickelDepartment of Gastroenterology and Hepatology, University Hospital of Zürich, Switzerland.
Jacob NattermannDepartment of Internal Medicine I, University Hospital, University of Bonn, Germany.
Christian P StrassburgDepartment of Internal Medicine I, University Hospital, University of Bonn, Germany.
Thomas BergDivision of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Philipp LutzDepartment of Internal Medicine I, University Hospital, University of Bonn, Germany.
Hans Dieter NischalkeDepartment of Internal Medicine I, University Hospital, University of Bonn, Germany.
University of Bonn · DELeipzig University · DEChristian-Albrechts-Universität zu Kiel · DEGlasgow Caledonian University · GBLudwig-Maximilians-Universität München · DETechnische Universität Dresden · DEUniversity Hospital of Zurich · CH

Funding

Cancer Research UK 29725MRF_ MRF-054-0001-F-INNE-C0825
6 · The paper itself

Abstract

Background & Aims: Progression of alcohol-associated liver disease (ALD) is driven by genetic predisposition. The rs13702 variant in the lipoprotein lipase (LPL) gene is linked to non-alcoholic fatty liver disease. We aimed at clarifying its role in ALD. Methods: Patients with alcohol-associated cirrhosis, with (n = 385) and without hepatocellular carcinoma (HCC) (n = 656), with HCC attributable to viral hepatitis C (n = 280), controls with alcohol abuse without liver damage (n = 366), and healthy controls (n = 277) were genotyped regarding the Results: Frequency of the Conclusions: LPL is upregulated in the liver of patients with alcohol-associated cirrhosis. The Impact and implications: Hepatocellular carcinoma is a severe complication of liver cirrhosis influenced by genetic predisposition. We found that a genetic variant in the gene encoding lipoprotein lipase reduces the risk for hepatocellular carcinoma in alcohol-associated cirrhosis. This genetic variation may directly affect the liver, because, unlike in healthy adult liver, lipoprotein lipase is produced from liver cells in alcohol-associated cirrhosis.

Indexed as

Alcohol-associated liver diseaseALD, alcohol-associated liver diseaseALT, alanine aminotransferaseAST, aspartate aminotransferaseBCLC, Barcelona Clinic Liver CancerBSA, bovine serum albuminCirrhosisFCS, foetal calf serumFIB-4, fibrosis 4GADPH, glyceraldehyde 3-phosphate dehydrogenaseGGT, gamma-glutamyl transferaseHbA1c, glycated haemoglobinHCCHCC, hepatocellular carcinomaHSCs, hepatic stellate cellsLPLLPL, lipoprotein lipaseLSECs, liver sinusoidal endothelial cellsMAF, minor allele frequencyNAFLD, non-alcoholic fatty liver diseaseNASH, non-alcoholic steatohepatitisOR, odds ratioPNPLA3, patatin-like phospholipase domain-containing protein 3rs13702rs328T2DM, type 2 diabetes mellitusUKB, UK Biobank

Identifiers

PMID36879887
PMCPMC9985032
OpenAlexW4318020059

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.