Evidence map›Paper›PMID 36881680›Full record

ArticleNano letters2023

Electrokinetic Active Particles for Motion-Based Biomolecule Detection.

Cooper P Thome, Wren S Hoertdoerfer, Julia R Bendorf, Jin Gyun Lee, C Wyatt Shields

Abstract read
In one paragraph

Article in Nano letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cooper P ThomeDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States.ORCID 0000-0001-6150-7719
Wren S HoertdoerferDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States.
Julia R BendorfDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States.
Jin Gyun LeeDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States.ORCID 0000-0002-5708-2284
C Wyatt ShieldsDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States.ORCID 0000-0003-4138-8462

Funding

Adoptive Macrophage Transfers for Nanoparticle DeliveryR35GM147455 · NIGMS · UNIVERSITY OF COLORADO · PI Charles Wyatt Shields IV · 2022 to 2026
$2.0M
Acoustofluidic Pipette for Rapid Serodiagnosis of Candida InfectionR21AI154266 · NIAID · UNIVERSITY OF COLORADO · PI SHIELDS IV, CHARLES WYATT · 2021 to 2022
$449k
NIAID NIH HHS R21 AI154266NIGMS NIH HHS R35 GM147455
6 · The paper itself

Abstract

Detection of biomolecules is essential for patient diagnosis, disease management, and numerous other applications. Recently, nano- and microparticle-based detection has been explored for improving traditional assays by reducing required sample volumes and assay times as well as enhancing tunability. Among these approaches, active particle-based assays that couple particle motion to biomolecule concentration expand assay accessibility through simplified signal outputs. However, most of these approaches require secondary labeling, which complicates workflows and introduces additional points of error. Here, we show a proof-of-concept for a label-free, motion-based biomolecule detection system using electrokinetic active particles. We prepare induced-charge electrophoretic microsensors (ICEMs) for the capture of two model biomolecules, streptavidin and ovalbumin, and show that the specific capture of the biomolecules leads to direct signal transduction through ICEM speed suppression at concentrations as low as 0.1 nM. This work lays the foundation for a new paradigm of rapid, simple, and label-free biomolecule detection using active particles.

Indexed as

Biosensing TechniquesHumansStreptavidinStreptavidinactive particlesbiomolecule detectionbiosensingInduced-charge electrophoresislabel-freemicromotors

Identifiers

PMID36881680
PMCPMC10038089

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.