Evidence map›Paper›PMID 36884200›Full record

SynthesisJournal of neuro-oncology2023

Systematic review of the management of brain metastases from hormone receptor positive breast cancer.

Shirley Jusino, Camilo E Fadul, Patrick Dillon

Open access · hybridFull text readSystematic Review
In one paragraph

Synthesis in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Real-world application ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Estrogen and glucocorticoid receptors co-regulate acrolein-induced respiratory and systemic homeostatic stress responses.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  5. Review
  6. Article
  7. Central Nervous System Metastases in Breast Cancer.Current treatment options in oncology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Shirley JusinoPonce Health Sciences University, Ponce, PR, 00716, USA.ORCID http://orcid.org/0000-0001-7960-9334
Camilo E FadulDivision of Neuro-Oncology, Department of Neurology, University of Virginia, Charlottesville, VA, 22908, USA.ORCID http://orcid.org/0000-0001-7459-7661
Patrick DillonDivision of Hematology/Oncology, University of Virginia, Charlottesville, VA, 22908, USA. PMD5B@uvahealth.org.ORCID http://orcid.org/0000-0003-0622-725X
University of Virginia · USPonce Health Sciences University · PR

Funding

Summer Research Experience in Cancer(SuRE-C)R25CA206972 · NCI · UNIVERSITY OF VIRGINIA · PI ADRIAN J HALME, Hui Zong · 2017 to 2026
$2.0M
NCI NIH HHS R25 CA206972Office of Extramural Research, National Institutes of Health 2P30CA044579-26
6 · The paper itself

Abstract

introductionBrain metastases are a common cause of morbidity and mortality in patients with breast cancer. Local central nervous system (CNS) directed therapies are usually the first line treatment for breast cancer brain metastases (BCBM), but those must be followed by systemic therapies to achieve long-term benefit. Systemic therapy for hormone receptor (HR

methodsWe performed a systematic review of the literature focused on management of HR

resultsOut of 807 articles identified, 98 fulfilled the inclusion criteria in their relevance to the management of HR

conclusionsSimilar to brain metastases from other neoplasms, local CNS directed therapies are the first line treatment for HR

Indexed as

Antineoplastic AgentsBrain NeoplasmsBreast NeoplasmsFemaleHumansRetrospective StudiesAntineoplastic AgentsBrain metastasesBreast cancerHR +Therapies

Identifiers

PMID36884200
PMCPMC10049940
OpenAlexW4323533348

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read49
identifiers read26
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.