ArticleScience advances2023
Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
What it found
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Illuminating Immunity: A Systematic Review of Immune Cell Autofluorescence.Journal of biophotonics · 2025Pooled it
- Plant-derived mitochondria mitigate aging-related neurodegeneration by reprogramming microglial mitochondrial energy metabolism.Translational neurodegeneration · 2026Article
- TMEM175 rescues post-infarct cardiac dysfunction via mTORC1-lysosomal axis modulation.Acta pharmacologica Sinica · 2026Article
- Repeated head impacts establish a senescent cranial bone marrow niche that impairs brain metabolism.Journal of neuroinflammation · 2026Article
- Multiorgan transcriptomics and circulating extracellular vesicle profiling reveal age-dependent systemic vulnerability to isoflurane anesthesia and surgery.GeroScience · 2026Article
- USP4 modulates ZBP1 ubiquitination to regulate microglial PANoptosis and functional outcomes following traumatic brain injury.Cell death and differentiation · 2026Article
- Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis.Acta neuropathologica · 2026Article
- Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation.Journal of advanced research · 2026Article
- Rubicon modulates neuroimmune responses following traumatic brain injury.bioRxiv : the preprint server for biology · 2026Article
- The Protective Effects of Dendrobine on LPS-Induced Neuroinflammation and Related Mechanisms Based on Microglial M1/M2 Polarization.Nutrients · 2026Article
- Phagocytosis and neuroinflammation: orchestrating central nervous system homeostasis, repair, and the resolution of inflammation.Trends in neurosciences · 2026Review
- Microglial Autofluorescence in the Brain and Retina is Dynamically Modulated by Systemic Inflammation.Cellular and molecular neurobiology · 2026Article
- Deficient de-S-acylation in aging and CLN1 contributes to lyso-mitochondrial dysfunction, lipid dyshomeostasis, and resultant lipofuscin biogenesis.Research square · 2026Article
- Inhibition of p38 MAPK after repetitive mTBI ameliorates immune signaling and functional deficits.Acta neuropathologica communications · 2026Article
- A microglial LCN2-MC4R signaling axis drives silica-induced neuronal damage via C1q release.Journal of neuroinflammation · 2026Article
- Repeated Mild Head Injury Establishes a Senescent Cranial Bone Marrow Niche that Impairs Brain Metabolism.bioRxiv : the preprint server for biology · 2026Article
- Comparison of automated and manual approaches for microglial quantification and classification: A focus on the HALO digital pathology platform.Brain pathology (Zurich, Switzerland) · 2026Article
- Xuebijing Alleviates Microglial Activation after Traumatic Brain Injury via Regulation of NF-κB Pathway: Network Pharmacology and Experimental Validation.Combinatorial chemistry & high throughput screening · 2026Article
- Multimodal characterization of intracranial biomechanics in a 3D biofidelic head surrogate.Journal of the mechanical behavior of biomedical materials · 2026Article
- Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model.Drug delivery · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 3 institutions in 2 countries.
Rodney M RitzelDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-0160-2930
Yun LiDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-2040-4451
Yun JiaoDepartment of Chemical, Biochemical, and Environmental Engineering, University of Maryland, Baltimore, MD 21250, USA.ORCID 0000-0002-9579-8398
Zhuofan LeiDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-4207-2796
Sarah J DoranDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Junyun HeDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Rami A ShahrorDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Rebecca J HenryDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Romeesa KhanDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77370, USA.ORCID 0000-0002-4129-1612
Chunfeng TanDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77370, USA.ORCID 0000-0001-7083-1529
Shaolin LiuDepartment of Anatomy, Howard University, Washington, DC 20059, USA.
Bogdan A StoicaDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-2501-6434
Alan I FadenDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Gregory SzetoDepartment of Chemical, Biochemical, and Environmental Engineering, University of Maryland, Baltimore, MD 21250, USA.ORCID 0000-0001-7604-1333
David J LoaneDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-0393-3503
Junfang WuDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-3338-7291
University of Maryland, Baltimore · USThe University of Texas Health Science Center at Houston · USHoward University · US
Funding
The new roles of the autophagy-lysosomal pathway in spinal cord injury-mediated dementiaR01NS094527 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI MARTA M LIPINSKI, Junfang Wu · 2016 to 2026
$3.5MThe inflammatory mechanisms underlying olfactory dysfunction in prognosis of TBI progression to dementiaR01AG077541 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Shaolin Liu, Junfang Wu · 2022 to 2026
$3.1MBidirectional Brain-Gut interactions, chronic neuroinflammation and neurodegeneration after traumatic brain injuryR01NS124687 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI ALAN Ira FADEN, BOGDAN ADRIAN STOICA · 2022 to 2026
$3.1MDementia Following Spinal Cord Injury: Mechanism and Therapeutic TargetingRF1NS110637 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JAY, STEVEN MICHAEL, WU, JUNFANG · 2019 to 2019
$2.8MReprogramming Microglial Epigenetic Pathways to Promote Cognitive Recovery after Brain Trauma.R01NS110756 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI FADEN, ALAN IRA, LOANE, DAVID J. · 2019 to 2023
$2.3MThe Function and Mechanisms of Autophagy in Spinal Cord InjuryRF1NS094527 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIPINSKI, MARTA M, WU, JUNFANG · 2022 to 2022
$2.2MMechanism of Inflammatory Related Brain Dysfunction after Spinal Cord InjuryR01NS110635 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI FADEN, ALAN IRA, WU, JUNFANG · 2019 to 2023
$2.2MNOX2 drives microglia-dependent neurodegeneration after traumatic brain injuryR01NS129094 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI BOGDAN ADRIAN STOICA · 2022 to 2026
$2.0MThe Function and Mechanisms of Voltage-Gated Proton Channel Hv1 in Spinal Cord InjuryR01NS110825 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI WU, JUNFANG · 2020 to 2024
$1.9MCellular and circuit mechanisms underlying APOE-4 effects on olfaction.RF1AG069196 · NIA · UNIVERSITY OF GEORGIA · PI LIU, SHAOLIN · 2020 to 2020
$1.8MMechanisms of Injury-induced Senescence and Immune-sequelae in Chronic TBIR00NS116032 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RITZEL, RODNEY · 2022 to 2024
$740kRole of aging-dependent changes in neuronal sub-types in development of radiotherapy-induced cognitive decline in the elderly populationR03AG070586 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI SABIRZHANOV, BORIS, STOICA, BOGDAN ADRIAN · 2021 to 2022
$309kBLRD VA I01 BX004866NIA NIH HHS R01 AG077541NIA NIH HHS R03 AG070586NIA NIH HHS RF1 AG069196NINDS NIH HHS F32 NS105355NINDS NIH HHS K99 NS116032NINDS NIH HHS R00 NS116032NINDS NIH HHS R01 NS094527NINDS NIH HHS R01 NS110635NINDS NIH HHS R01 NS110756NINDS NIH HHS R01 NS110825NINDS NIH HHS R01 NS124687NINDS NIH HHS R01 NS129094NINDS NIH HHS RF1 NS094527NINDS NIH HHS RF1 NS110637RRD VA I01 RX001993RRD VA I01 RX003379
Abstract
Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months old) and demonstrate that in comparison to young mice, one-third of old microglia are AF, characterized by profound changes in lipid and iron content, phagocytic activity, and oxidative stress. Pharmacological depletion of microglia in old mice eliminated the AF microglia following repopulation and reversed microglial dysfunction. Age-related neurological deficits and neurodegeneration after traumatic brain injury (TBI) were attenuated in old mice lacking AF microglia. Furthermore, increased phagocytic activity, lysosomal burden, and lipid accumulation in microglia persisted for up to 1 year after TBI, were modified by
Indexed as
Brain InjuriesBrain Injuries, TraumaticAnimalsBrainLipidsMiceMice, Inbred C57BLMicrogliaPhenotypeLipids
Identifiers
What Socratic holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.