Evidence map›Paper›PMID 36889280›Full record

ReviewCell metabolism2023

Adipose tissue at single-cell resolution.

Babukrishna Maniyadath, Qianbin Zhang, Rana K Gupta, Susanne Mandrup

Open access · greenAbstract readReview
In one paragraph

Review in Cell metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 1 pooled it
30.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.

  1. Guideline
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  5. Exercise and Fat: A Primer.Sports medicine - open · 2026
    Review
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Babukrishna ManiyadathCenter for Functional Genomics and Tissue Plasticity, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark.
Qianbin ZhangDepartment of Internal Medicine, Touchstone Diabetes Center, UT Southwestern Medical Center, Dallas, TX, USA.
Rana K GuptaDepartment of Internal Medicine, Touchstone Diabetes Center, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: rana.gupta@duke.edu.
Susanne MandrupCenter for Functional Genomics and Tissue Plasticity, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, Denmark. Electronic address: s.mandrup@bmb.sdu.dk.
University of Southern Denmark · DKSouthwestern Medical CenterThe University of Texas Southwestern Medical Center · US

Funding

Generation of Novel Genetic Tools to Study Cellular Heterogeneity in Adipose TissuesRC2DK118620 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K, SCHERER, PHILIPP E · 2019 to 2023
$7.0M
Establishment and Maintenance of Healthy Adipose Tissue in ObesityR01DK104789 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2015 to 2024
$3.9M
Multifaceted Roles for Pdgfrb+ Perivascular Cells in White Adipose Tissue RemodelingR01DK119163 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2019 to 2022
$1.8M
NIDDK NIH HHS R01 DK104789NIDDK NIH HHS R01 DK119163NIDDK NIH HHS RC2 DK118620
6 · The paper itself

Abstract

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular composition under physiological and pathophysiological conditions. The emergence of single-cell transcriptomics has rapidly transformed our understanding of the diverse array of cell types and cell states residing in adipose tissues and has provided insight into how transcriptional changes in individual cell types contribute to tissue plasticity. Here, we present a comprehensive overview of the cellular atlas of adipose tissues focusing on the biological insight gained from single-cell and single-nuclei transcriptomics of murine and human adipose tissues. We also offer our perspective on the exciting opportunities for mapping cellular transitions and crosstalk, which have been made possible by single-cell technologies.

Indexed as

AdipocytesAdipogenesisAdipose TissueAnimalsCell DifferentiationGene Expression ProfilingHumansMiceadipocytesadipogenesisadipose tissue plasticitycellular heterogeneityfibro-adipogenic progenitorsinflammationmacrophagespreadipocytessingle-cell sequencingsingle-nuclei sequencing

Identifiers

PMID36889280
PMCPMC10027403
OpenAlexW4323530524

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.