Evidence map›Paper›PMID 36891731›Full record

ReviewCytoskeleton (Hoboken, N.J.)

Molecular and cellular level characterization of cytoskeletal mechanics using a quartz crystal microbalance.

Emily M Kerivan, Lyle Tobin, Mihir Basil, Dana N Reinemann

Open access · hybridAbstract readReview
In one paragraph

Review in Cytoskeleton (Hoboken, N.J.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Measuring emergent mechanical changes in cytoskeletal ensemblesFrontiers in cell and developmental biology · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Emily M KerivanDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi, 38677, USA.
Lyle TobinDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi, 38677, USA.
Mihir BasilDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi, 38677, USA.
Dana N ReinemannDepartment of Biomedical Engineering, University of Mississippi, University, Mississippi, 38677, USA.ORCID 0000-0002-3516-3948
University of Mississippi · US

Funding

Biophysical Mechanisms of Force Transmission in Cytoskeletal EnsemblesR35GM147050 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Dana Nicole Reinemann · 2022 to 2026
$1.7M
American Heart Association-American Stroke Association 848586NIGMS NIH HHS R35 GM147050
6 · The paper itself

Abstract

A quartz crystal microbalance (QCM) is an instrument that has the ability to measure nanogram-level changes in mass on a quartz sensor and is traditionally used to probe surface interactions and assembly kinetics of synthetic systems. The addition of dissipation monitoring (QCM-D) facilitates the study of viscoelastic systems, such as those relevant to molecular and cellular mechanics. Due to real-time recording of frequency and dissipation changes and single protein-level precision, the QCM-D is effective in interrogating the viscoelastic properties of cell surfaces and in vitro cellular components. However, few studies focus on the application of this instrument to cytoskeletal systems, whose dynamic parts create interesting emergent mechanics as ensembles that drive essential tasks, such as division and motility. Here, we review the ability of the QCM-D to characterize key kinetic and mechanical features of the cytoskeleton through in vitro reconstitution and cellular assays and outline how QCM-D studies can yield insightful mechanical data alone and in tandem with other biophysical characterization techniques.

Indexed as

Biosensing TechniquesQuartz Crystal Microbalance TechniquesCell MembraneCytoskeletonMicrotubulescytoskeletondissipationquartz crystal microbalancequartz crystal microbalance-dissipation monitoring

Identifiers

PMID36891731
PMCPMC10272097
OpenAlexW4323652299

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.