Evidence map›Paper›PMID 36892890›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2023

Hypercapnic signaling influences hypoxic signaling in the control of breathing in C57BL6 mice.

Paulina M Getsy, Jesse Davis, Gregory A Coffee, Tristan H J Lewis, Stephen J Lewis

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Reversal of morphine-induced respiratory depression with the µAmerican journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Paulina M GetsyDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0001-8278-0810
Jesse DavisDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States.
Gregory A CoffeeDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States.
Tristan H J LewisDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0001-9697-5045
Stephen J LewisDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0001-7050-0666

Funding

Functional Mapping of the afferent and Efferent Projections of the Superior Cervical Ganglion InteractomeOT2OD023860 · OD · CASE WESTERN RESERVE UNIVERSITY · PI LEWIS, STEPHEN JOHN · 2016 to 2019
$2.6M
NIH HHS 10T20D023860NIH HHS OT2 OD023860
6 · The paper itself

Abstract

Interactions between hypoxic and hypercapnic signaling pathways, expressed as ventilatory changes occurring during and following a simultaneous hypoxic-hypercapnic gas challenge (HH-C) have not been determined systematically in mice. This study in unanesthetized male C57BL6 mice addressed the hypothesis that hypoxic (HX) and hypercapnic (HC) signaling events display an array of interactions indicative of coordination by peripheral and central respiratory mechanisms. We evaluated the ventilatory responses elicited by hypoxic (HX-C, 10%, O2, 90% N2), hypercapnic (HC-C, 5% CO

Indexed as

Carbon DioxideRespirationAnimalsHypercapniaHypoxiaMaleMiceMice, Inbred C57BLCarbon DioxideC57BL6 micehypercapnic gas challengehypoxic gas challengehypoxic-hypercapnic gas challengeventilatory responses

Identifiers

PMID36892890
PMCPMC10151047

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.