Evidence map›Paper›PMID 36893230›Full record

ArticleScience (New York, N.Y.)2023

The connectome of an insect brain.

Michael Winding, Benjamin D Pedigo, Christopher L Barnes, Heather G Patsolic, Youngser Park, Tom Kazimiers, Akira Fushiki, Ingrid V Andrade, Avinash Khandelwal, Javier Valdes-Aleman and 10 more

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed
62.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 424 citations in OpenAlex.

  1. Distribution and voltage dependence of ion channels shape single-neuron computations.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. The larvalScience advances · 2026
    Article
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  19. Review
  20. A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article

141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Michael WindingUniversity of Cambridge, Department of Zoology, Cambridge, UK.ORCID 0000-0003-1965-3266
Benjamin D PedigoJohns Hopkins University, Department of Biomedical Engineering, Baltimore, MD, USA.ORCID 0000-0002-9519-1190
Christopher L BarnesMRC Laboratory of Molecular Biology, Neurobiology Division, Cambridge, UK.ORCID 0000-0002-1296-7310
Heather G PatsolicJohns Hopkins University, Department of Applied Mathematics and Statistics, Baltimore, MD, USA.ORCID 0000-0001-8005-5455
Youngser ParkJohns Hopkins University, Center for Imaging Science, Baltimore, MD, USA.
Tom KazimiersJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-1605-9475
Akira FushikiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-7987-6405
Ingrid V AndradeUniversity of California Los Angeles, Department of Molecular, Cell and Developmental Biology, Los Angeles, CA, USA.
Avinash KhandelwalJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-8756-1278
Javier Valdes-AlemanUniversity of Cambridge, Department of Zoology, Cambridge, UK.ORCID 0000-0002-1577-1057
Feng LiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Nadine RandelUniversity of Cambridge, Department of Zoology, Cambridge, UK.ORCID 0000-0002-7817-4137
Elizabeth BarsottiMRC Laboratory of Molecular Biology, Neurobiology Division, Cambridge, UK.ORCID 0000-0002-4106-5543
Ana CorreiaMRC Laboratory of Molecular Biology, Neurobiology Division, Cambridge, UK.ORCID 0000-0001-7944-9326
Richard D FetterJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-1558-100X
Volker HartensteinUniversity of California Los Angeles, Department of Molecular, Cell and Developmental Biology, Los Angeles, CA, USA.ORCID 0000-0001-9676-7393
Carey E PriebeJohns Hopkins University, Department of Applied Mathematics and Statistics, Baltimore, MD, USA.
Joshua T VogelsteinJohns Hopkins University, Department of Biomedical Engineering, Baltimore, MD, USA.ORCID 0000-0003-2487-6237
Albert CardonaMRC Laboratory of Molecular Biology, Neurobiology Division, Cambridge, UK.ORCID 0000-0003-4941-6536
Marta ZlaticUniversity of Cambridge, Department of Zoology, Cambridge, UK.ORCID 0000-0002-3149-2250
Howard Hughes Medical Institute · USJohns Hopkins University · USMRC Laboratory of Molecular Biology · GBUniversity of California, Los Angeles · US

Funding

Lineage-associated wiring properties of Drosphila brain neuronsR01NS054814 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HARTENSTEIN, VOLKER, LOUIS, MATTHIEU R. P. J. C. G. · 2006 to 2025
$6.6M
Graspy: A python package for rigorous statistical analysis of populations of attributed connectomesRF1MH123233 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PRIEBE, CAREY, VOGELSTEIN, JOSHUA T · 2020 to 2020
$1.2M
Medical Research Council MC_UP_1201/20NIMH NIH HHS RF1 MH123233NINDS NIH HHS R01 NS054814Wellcome Trust 205038Wellcome Trust 205050
6 · The paper itself

Abstract

Brains contain networks of interconnected neurons and so knowing the network architecture is essential for understanding brain function. We therefore mapped the synaptic-resolution connectome of an entire insect brain (

Indexed as

BrainConnectomeDrosophila melanogasterNerve NetAnimalsNeuronsSynapses

Identifiers

PMID36893230
PMCPMC7614541
OpenAlexW4323809195

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.