Evidence map›Paper›PMID 36893279›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

RNA interference is essential to modulating the pathogenesis of mosquito-borne viruses in the yellow fever mosquito

Glady Hazitha Samuel, Tyler Pohlenz, Yuemei Dong, Nese Coskun, Zach N Adelman, George Dimopoulos, Kevin M Myles

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Antagonism of RNA silencing in the yellow fever mosquito,Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. The PAZ domain ofRNA (New York, N.Y.) · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. The making of a dangerous vector: factors shaping the vector competence ofFrontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Glady Hazitha SamuelDepartment of Entomology, Minnie Belle Heep Center, Texas A & M University, College Station, TX 77843-2475.
Tyler PohlenzDepartment of Entomology, Minnie Belle Heep Center, Texas A & M University, College Station, TX 77843-2475.
Yuemei DongW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205-2179.
Nese CoskunDepartment of Entomology, Minnie Belle Heep Center, Texas A & M University, College Station, TX 77843-2475.ORCID 0000-0002-4140-1439
Zach N AdelmanDepartment of Entomology, Minnie Belle Heep Center, Texas A & M University, College Station, TX 77843-2475.ORCID 0000-0001-5901-7171
George DimopoulosW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205-2179.ORCID 0000-0001-6755-8111
Kevin M MylesDepartment of Entomology, Minnie Belle Heep Center, Texas A & M University, College Station, TX 77843-2475.ORCID 0000-0002-9820-2502
Texas A&M University · USJohns Hopkins University · US

Funding

Aedes antiviral RNAi pathwayR01AI141532 · NIAID · JOHNS HOPKINS UNIVERSITY · PI George Dimopoulos, KEVIN M MYLES · 2019 to 2026
$4.6M
Hierarchical antiviral immunity in disease vector mosquitoesR01AI119081 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MYLES, KEVIN M · 2015 to 2019
$1.9M
HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (DMID) AI119081HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (DMID) AI141532NIAID NIH HHS R01 AI141532
6 · The paper itself

Abstract

While it has long been known that the transmission of mosquito-borne viruses depends on the establishment of persistent and nonlethal infections in the invertebrate host, specific roles for the insects' antiviral immune pathways in modulating the pathogenesis of viral infections is the subject of speculation and debate. Here, we show that a loss-of-function mutation in the

Indexed as

AedesFlavivirusYellow FeverAnimalsHumansRNA InterferenceRNA, Small InterferingRNA, Small InterferingDicerimmunitymosquitoRNAivirus

Identifiers

PMID36893279
PMCPMC10089172
OpenAlexW4323656718

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.