ArticleNature communications2023
Arboviruses and symbiotic viruses cooperatively hijack insect sperm-specific proteins for paternal transmission.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Active but not passive passengers: Persistent-propagative plant viruses manipulate insect vectors for efficient transmission.PLoS pathogens · 2026Review
- Plant Virus-Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Molecular identification of severe fever with thrombocytopenia syndrome virus in deer ked: Implications for disease transmission.One health (Amsterdam, Netherlands) · 2025Article
- Review
- An insect symbiotic virus promotes the transmission of a phytoarbovirus via inhibiting E3 ubiquitin ligase Sina.PLoS pathogens · 2025Article
- Rice stripe mosaic virus M protein antagonizes G-protein-induced antiviral autophagy in insect vectors.PLoS pathogens · 2025Article
- Leafhopper salivary carboxylesterase suppresses JA-Ile synthesis to facilitate initial arbovirus transmission in rice phloem.Plant communications · 2024Article
- Article
- Insect ribosome-rescuer Pelo-Hbs1 complex on sperm surface mediates paternal arbovirus transmission.Nature communications · 2024Article
- Identification and Characterization of Three Novel Solemo-like Viruses in the White-Backed Planthopper,Insects · 2024Article
- Managing Super Pests: Interplay between Pathogens and Symbionts Informs Biocontrol of Whiteflies.Microorganisms · 2024Article
- Diversity of RNA viruses in agricultural insects.Computational and structural biotechnology journal · 2023Review
- Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arboviruses and symbiotic viruses can be paternally transmitted by male insects to their offspring for long-term viral persistence in nature, but the mechanism remains largely unknown. Here, we identify the sperm-specific serpin protein HongrES1 of leafhopper Recilia dorsalis as a mediator of paternal transmission of the reovirus Rice gall dwarf virus (RGDV) and a previously undescribed symbiotic virus of the Virgaviridae family, Recilia dorsalis filamentous virus (RdFV). We show that HongrES1 mediates the direct binding of virions to leafhopper sperm surfaces and subsequent paternal transmission via interaction with both viral capsid proteins. Direct interaction of viral capsid proteins mediates simultaneously invasion of two viruses into male reproductive organs. Moreover, arbovirus activates HongrES1 expression to suppress the conversion of prophenoloxidase to active phenoloxidase, potentially producing a mild antiviral melanization defense. Paternal virus transmission scarcely affects offspring fitness. These findings provide insights into how different viruses cooperatively hijack insect sperm-specific proteins for paternal transmission without disturbing sperm functions.
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