Evidence map›Paper›PMID 36896185›Full record

ArticleFrontiers in endocrinology2023

Serotonin and the ventilatory effects of etonogestrel, a gonane progestin, in a murine model of congenital central hypoventilation syndrome.

Alexis Casciato, Lola Bianchi, Manon Reverdy, Fanny Joubert, Roman Delucenay-Clarke, Sandrine Parrot, Nélina Ramanantsoa, Eléonore Sizun, Boris Matrot, Christian Straus and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Alexis CasciatoSorbonne Université, Inserm, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Lola BianchiSorbonne Université, Inserm, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Manon ReverdySorbonne Université, Inserm, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Fanny JoubertSorbonne Université, Inserm, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Roman Delucenay-ClarkeSorbonne Université, Inserm, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Sandrine ParrotCentre de Recherche en Neurosciences, NeuroDialyTics, Bron, France.
Nélina RamanantsoaUniversité de Paris, NeuroDiderot, Inserm, Paris, France.
Eléonore SizunUniversité de Paris, NeuroDiderot, Inserm, Paris, France.
Boris MatrotUniversité de Paris, NeuroDiderot, Inserm, Paris, France.
Christian StrausSorbonne Université, Inserm, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Thomas SimilowskiSorbonne Université, Inserm, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Florence CayetanotSorbonne Université, Inserm, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Laurence BodineauSorbonne Université, Inserm, UMR_S1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Inserm · FRSorbonne Université · FRNeuroDiderot · FRNeurophysiologie respiratoire expérimentale et cliniqueUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Congenital Central Hypoventilation Syndrome, a rare disease caused by Methods: Here, we used a preclinical model of Congenital Central Hypoventilation Syndrome, the retrotrapezoid nucleus conditional Results: We observed etonogestrel restored chemosensitivity in Discussion: Our work thus highlights that serotonin systems were critically important for the occurrence of an etonogestrel-restoration, an element to consider in potential therapeutic intervention in Congenital Central Hypoventilation Syndrome patients.

Indexed as

DesogestrelProgestinsAnimalsCarbon DioxideDisease Models, AnimalGonanesHomeodomain ProteinsHypoventilationMiceProgesterone CongenersSerotoninSleep Apnea, CentralTranscription FactorsCarbon DioxideDesogestreletonogestrelGonanesHomeodomain ProteinsProgesterone CongenersProgestinsSerotoninTranscription Factorscentral breathing disorderCO2/H+ chemosensitivitymouse modelprogestinserotoninergic systems

Identifiers

PMID36896185
PMCPMC9989262
OpenAlexW4321458634

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.