Evidence map›Paper›PMID 36899835›Full record

ArticleCells2023

The Protein Network in Subcutaneous Fat Biopsies from Patients with AL Amyloidosis: More Than Diagnosis?

Dario Di Silvestre, Francesca Brambilla, Francesca Lavatelli, Maila Chirivì, Diana Canetti, Claudia Bearzi, Roberto Rizzi, Johan Bijzet, Bouke P C Hazenberg, Vittorio Bellotti and 2 more

Open access · goldFull text read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Dario Di SilvestreInstitute for Biomedical Technologies (ITB), Biomedical Sciences, National Research Council (CNR), 20054 Segrate, Italy.ORCID 0000-0002-7143-6229
Francesca BrambillaInstitute for Biomedical Technologies (ITB), Biomedical Sciences, National Research Council (CNR), 20054 Segrate, Italy.
Francesca LavatelliDepartment of Molecular Medicine, University of Pavia, Via Forlanini 6, 27100 Pavia, Italy.
Maila ChirivìUOC Neurology, Fondazione Ca'Granda, Ospedale Maggiore Policlinico, Via F. Sforza, 28, 20122 Milan, Italy.
Diana CanettiCentre for Amyloidosis, Division of Medicine, University College London, London NW3 2PF, UK.ORCID 0000-0001-5292-8124
Claudia BearziInstitute for Biomedical Technologies (ITB), Biomedical Sciences, National Research Council (CNR), 20054 Segrate, Italy.
Roberto RizziFondazione Istituto Nazionale di Genetica Molecolare, Via F. Sforza 35, 20122 Milan, Italy.
Johan BijzetAmyloidosis Center of Expertise, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Bouke P C HazenbergAmyloidosis Center of Expertise, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-1827-0482
Vittorio BellottiCentre for Amyloidosis, Division of Medicine, University College London, London NW3 2PF, UK.ORCID 0000-0001-8678-662X
Julian D GillmoreCentre for Amyloidosis, Division of Medicine, University College London, London NW3 2PF, UK.
Pierluigi MauriInstitute for Biomedical Technologies (ITB), Biomedical Sciences, National Research Council (CNR), 20054 Segrate, Italy.ORCID 0000-0003-4364-0393
Institute of Biomedical Technologies · ITUniversity College London · GBUniversity Medical Center Groningen · NLFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIstituto Nazionale Genetica Molecolare · ITPoliclinico San Matteo Fondazione · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AL amyloidosis is caused by the misfolding of immunoglobulin light chains leading to an impaired function of tissues and organs in which they accumulate. Due to the paucity of -omics profiles from undissected samples, few studies have addressed amyloid-related damage system wide. To fill this gap, we evaluated proteome changes in the abdominal subcutaneous adipose tissue of patients affected by the AL isotypes

Indexed as

Immunoglobulin Light-chain AmyloidosisBiopsyHumansProteomicsRetrospective StudiesSubcutaneous Fatamyloidosisco-expressionnetworksPPIproteomicssystems biology

Identifiers

PMID36899835
PMCPMC10000381
OpenAlexW4321598087

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read18
table measurements read4
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.