ArticleCells2023
Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in
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Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Genetic Association Between Rheumatoid Arthritis and Preeclampsia: A Bidirectional Mendelian Randomization and Bioinformatics Study.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Biological properties of α-actinin-2 and its role and mechanisms in disease development.Frontiers in physiology · 2026Review
- Atrial electrical alterations with intact cardiac structure and contractile function in a mouse model of an HCM-linkedJournal of molecular and cellular cardiology plus · 2025Article
- Filamin C dimerisation is regulated by HSPB7.Nature communications · 2025Article
- Review: Utility of mass spectrometry in rare disease research and diagnosis.NPJ genomic medicine · 2025Review
- α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment.Blood advances · 2025Article
- Structural and functional insights into α-actinin isoforms and their implications in cardiovascular disease.The Journal of general physiology · 2025Review
- Development, in vitro, and in vivo assessments of PCL-gelatin-βTCP fibrous scaffolds for cardiac regeneration.BioImpacts : BI · 2025Article
- Article
- PITX2 deficiency leads to atrial mitochondrial dysfunction.Cardiovascular research · 2024Article
- Protein-extending ACTN2 frameshift variants cause variable myopathy phenotypes by protein aggregation.Annals of clinical and translational neurology · 2024Article
- Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2.International journal of molecular sciences · 2023Article
- Cardiomyopathy-associated variants alter the structure and function of the α-actinin-2 actin-binding domain.Biochemical and biophysical research communications · 2023Article
- Impaired Cardiomyocyte Maturation Leading to DCM: A Case Report and Literature Review.Medicina (Kaunas, Lithuania) · 2023Review
- Advanced searching for hypertrophic cardiomyopathy heritability in real practice tomorrow.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 7 institutions in 4 countries.
Sophie Broadway-StringerInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.
He JiangDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford, University of Oxford, Oxford OX3 9DU, UK.
Kirsty WadmoreInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Charlotte HooperDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford, University of Oxford, Oxford OX3 9DU, UK.
Gillian DouglasDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0002-9090-5326
Violetta SteeplesDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford, University of Oxford, Oxford OX3 9DU, UK.
Amar J AzadInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0003-1472-7668
Evie SingerInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Jasmeet S ReyatInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0003-3247-9186
Frantisek GalatikDepartment of Physiology, Faculty of Science, Charles University, 12800 Prague, Czech Republic.ORCID 0000-0002-8175-2604
Elisabeth EhlerRandall Centre for Cell and Molecular Biophysics, King's College London, London SE1 9RT, UK.ORCID 0000-0001-5646-5964
Pauline BennettRandall Centre for Cell and Molecular Biophysics, King's College London, London SE1 9RT, UK.
Jacinta I Kalisch-SmithDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.
Duncan B SparrowDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.ORCID 0000-0002-1141-6613
Benjamin DaviesTransgenic Core, Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Kristina Djinovic-CarugoEuropean Molecular Biology Laboratory, 38000 Grenoble, France.ORCID 0000-0003-0252-2972
Mathias GautelSchool of Basic and Medical Biosciences, British Heart Foundation Centre of Research Excellence, King's College London, London SE1 9RT, UK.
Hugh WatkinsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine and British Heart Foundation Centre of Research Excellence Oxford, University of Oxford, Oxford OX3 9DU, UK.
Katja GehmlichInstitute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0003-4019-1844
British Heart Foundation · GBUniversity of Birmingham · GBKing's College London · GBUniversity of Oxford · GBCentre for Human Genetics · GBCharles University · CZUniversity of Vienna · AT
Funding
British Heart Foundation AA/18/2/34218British Heart Foundation CH/08/001/25300British Heart Foundation FS/12/40/29712British Heart Foundation FS/17/55/33100British Heart Foundation PG/15/113/31944British Heart Foundation RG/18/9/33887Medical Research Council MR/R017050/1Medical Research Council MR/V009540/1Wellcome Trust 201543/Z/16/Z
Abstract
Pathogenic variants in
Indexed as
CardiomyopathiesCardiomyopathy, HypertrophicActininAnimalsHeartMaleMiceUbiquitinsActininActn2 protein, mouseUbiquitinsalpha-actinincardiomyopathyembryonic heartmitochondriaproteomicssarcomere
Identifiers
What Socratic holds
Textfull text, public
LicenceCC BY
measurements read37
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.