Evidence map›Paper›PMID 36899880›Full record

ArticleCells2023

Heparan Sulfates Regulate Axonal Excitability and Context Generalization through Ca

Inseon Song, Tatiana Kuznetsova, David Baidoe-Ansah, Hadi Mirzapourdelavar, Oleg Senkov, Hussam Hayani, Andrey Mironov, Rahul Kaushik, Michael Druzin, Staffan Johansson and 1 more

Open access · goldFull text read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Inseon SongMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Tatiana KuznetsovaDepartment of Integrative Medical Biology, Umeå University, 90187 Umeå, Sweden.
David Baidoe-AnsahMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Hadi MirzapourdelavarMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Oleg SenkovMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Hussam HayaniMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Andrey MironovMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Rahul KaushikMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
Michael DruzinDepartment of Integrative Medical Biology, Umeå University, 90187 Umeå, Sweden.
Staffan JohanssonDepartment of Integrative Medical Biology, Umeå University, 90187 Umeå, Sweden.ORCID 0000-0003-1022-5097
Alexander DityatevMolecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.ORCID 0000-0002-0472-0553
German Center for Neurodegenerative Diseases · DEUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous studies demonstrated that enzymatic removal of highly sulfated heparan sulfates with heparinase 1 impaired axonal excitability and reduced expression of ankyrin G at the axon initial segments in the CA1 region of the hippocampus ex vivo, impaired context discrimination in vivo, and increased Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2Heparan SulfateAnimalsAnkyrinsHeparin LyaseHippocampusMiceAnkyrinsCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2g protein, mouseHeparan SulfateHeparin Lyaseankyrin Gaxonal excitabilityaxon initial segmentcontext discriminationextracellular matrixsynaptic plasticity

Identifiers

PMID36899880
PMCPMC10000602
OpenAlexW4322501098

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read37
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.