Evidence map›Paper›PMID 36901819›Full record

ArticleInternational journal of molecular sciences2023

The Effect of the Stress Induced by Hydrogen Peroxide and Corticosterone on Tryptophan Metabolism, Using Human Neuroblastoma Cell Line (SH-SY5Y).

Ana Salomé Correia, Isabel Silva, Henrique Reguengo, José Carlos Oliveira, Francisco Vasques-Nóvoa, Armando Cardoso, Nuno Vale

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In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Neuroprotective Effects and Mechanisms of Arecoline Against HInternational journal of molecular sciences · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Salomé CorreiaOncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.ORCID 0000-0002-8231-1560
Isabel SilvaClinical Chemistry, Department of Laboratory Pathology, Hospital Center of the University of Porto (CHUP), Largo Prof. Abel Salazar, 4099-313 Porto, Portugal.
Henrique ReguengoClinical Chemistry, Department of Laboratory Pathology, Hospital Center of the University of Porto (CHUP), Largo Prof. Abel Salazar, 4099-313 Porto, Portugal.ORCID 0000-0002-0246-6790
José Carlos OliveiraInstitute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.ORCID 0000-0003-2142-6839
Francisco Vasques-NóvoaCardiovascular R and D Center, Faculty of Medicine, University of Porto, Rua Doutor Plácido da Costa, s/n, 4200-450 Porto, Portugal.
Armando CardosoCINTESIS@RISE, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID 0000-0002-2967-6990
Nuno ValeOncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.ORCID 0000-0002-1283-1042

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-tryptophan (L-Trp) is an important amino acid in several physiological mechanisms, being metabolized into two important pathways: the kynurenine and the serotonin (5-HT) pathways. It is important in processes such as mood and stress response, the 5-HT pathway begins with the conversion of L-Trp to 5-hydroxytryptophan (5-HTP), that is metabolized into 5-HT, converted to melatonin or to 5-hydroxyindoleacetic acid (5-HIAA). Disturbances in this pathway are reported to be connected with oxidative stress and glucocorticoid-induced stress, are important to explore. Thus, our study aimed to understand the role of hydrogen peroxide (H

Indexed as

NeuroblastomaTryptophan5-HydroxytryptophanCorticosteroneHumansHydrogen PeroxideHydroxyindoleacetic AcidSerotonin5-HydroxytryptophanCorticosteroneHydrogen PeroxideHydroxyindoleacetic AcidSerotoninTryptophan5-hydroxyindoleacetic acid5-hydroxytryptophanglucocorticoidsoxidative stressserotonintryptophan

Identifiers

PMID36901819
PMCPMC10001894

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read38
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.