Evidence map›Paper›PMID 36901916›Full record

ArticleInternational journal of molecular sciences2023

Variable Intrinsic Expression of Immunoregulatory Biomarkers in Breast Cancer Cell Lines, Mammospheres, and Co-Cultures.

Yoel Genaro Montoyo-Pujol, Marta García-Escolano, José J Ponce, Silvia Delgado-García, Tina Aurora Martín, Hortensia Ballester, Elena Castellón-Molla, Pascual Martínez-Peinado, Sandra Pascual-García, José Miguel Sempere-Ortells and 1 more

Open access · goldFull text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yoel Genaro Montoyo-PujolResearch Unit, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Pintor Baeza 12, 03010 Alicante, Spain.ORCID 0000-0003-3169-0924
Marta García-EscolanoResearch Unit, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Pintor Baeza 12, 03010 Alicante, Spain.
José J PonceMedical Oncology Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Pintor Baeza 12, 03010 Alicante, Spain.
Silvia Delgado-GarcíaGynecology and Obstetrics Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Pintor Baeza 12, 03010 Alicante, Spain.
Tina Aurora MartínGynecology and Obstetrics Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Pintor Baeza 12, 03010 Alicante, Spain.
Hortensia BallesterGynecology and Obstetrics Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Pintor Baeza 12, 03010 Alicante, Spain.
Elena Castellón-MollaPathology Department, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Pintor Baeza 12, 03010 Alicante, Spain.
Pascual Martínez-PeinadoBiotechnology Department, Immunology Division, University of Alicante, Ctra San Vicente s/n., 03080 San Vicente del Raspeig, Spain.ORCID 0000-0003-4370-5468
Sandra Pascual-GarcíaBiotechnology Department, Immunology Division, University of Alicante, Ctra San Vicente s/n., 03080 San Vicente del Raspeig, Spain.ORCID 0000-0002-0536-1185
José Miguel Sempere-OrtellsBiotechnology Department, Immunology Division, University of Alicante, Ctra San Vicente s/n., 03080 San Vicente del Raspeig, Spain.
Gloria PeiróResearch Unit, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Pintor Baeza 12, 03010 Alicante, Spain.ORCID 0000-0002-2899-2908
Instituto de investigación sanitaria y biomédica de AlicanteUniversity of Alicante · ESHospital General Universitario de Alicante Doctor Balmis · ES

Funding

Alicante Institute for Health and Biomedical Research (ISABIAL) 2020-0324Alicante Institute for Health and Biomedical Research (ISABIAL) 2021-0389Alicante Institute for Health and Biomedical Research (ISABIAL) 2021-0453Alicante Institute for Health and Biomedical Research (ISABIAL) NR-180202Alicante Institute for Health and Biomedical Research (ISABIAL) NR-19-292
6 · The paper itself

Abstract

Advances in immunotherapy have increased interest in knowing the role of the immune system in breast cancer (BC) pathogenesis. Therefore, immune checkpoints (IC) and other pathways related to immune regulation, such as JAK2 and FoXO1, have emerged as potential targets for BC treatment. However, their intrinsic gene expression in vitro has not been extensively studied in this neoplasia. Thus, we evaluated the mRNA expression of tumor-cell-intrinsic

Indexed as

B7-H1 AntigenBiomarkers, TumorBreast NeoplasmsB7 AntigensCoculture TechniquesCTLA-4 AntigenHumansLeukocytes, MononuclearMCF-7 CellsB7 AntigensB7-H1 AntigenBiomarkers, TumorCD276 protein, humanCTLA-4 Antigenbreast carcinomacell linesco-cultureimmune checkpointsmammospheresmRNA expression

Identifiers

PMID36901916
PMCPMC10003642
OpenAlexW4322501853

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read42
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.