Evidence map›Paper›PMID 36902012›Full record

SynthesisInternational journal of molecular sciences2023

Polydeoxyribonucleotide in the Treatment of Tendon Disorders, from Basic Science to Clinical Practice: A Systematic Review.

Davide Bizzoca, Giovanni Brunetti, Lorenzo Moretti, Andrea Piazzolla, Giovanni Vicenti, Francesco Luca Moretti, Giuseppe Solarino, Biagio Moretti

Full text readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Prolotherapy for temporomandibular joint disorders: an updated comprehensive review.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025
    Review
  6. Review
  7. Review of Preclinical and Clinical Studies Supporting the Role of Polydeoxyribonucleotide in the Treatment of Tendon Disorders.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Davide BizzocaUOSD Spine Surgery, AOU Consorziale Policlinico, 70124 Bari, Italy.ORCID 0000-0002-7516-2333
Giovanni BrunettiUOSD Spine Surgery, AOU Consorziale Policlinico, 70124 Bari, Italy.
Lorenzo MorettiOrthopaedics Unit, Department DiBraiN, School of Medicine, University of Bari "Aldo Moro", AOU Consorziale Policlinico, 70124 Bari, Italy.ORCID 0000-0003-4215-7615
Andrea PiazzollaUOSD Spine Surgery, AOU Consorziale Policlinico, 70124 Bari, Italy.
Giovanni VicentiOrthopaedics Unit, Department DiBraiN, School of Medicine, University of Bari "Aldo Moro", AOU Consorziale Policlinico, 70124 Bari, Italy.
Francesco Luca MorettiNational Centre for Chemicals, Cosmetic Products and Consumer Protection, National Institute of Health, 00161 Rome, Italy.
Giuseppe SolarinoOrthopaedics Unit, Department DiBraiN, School of Medicine, University of Bari "Aldo Moro", AOU Consorziale Policlinico, 70124 Bari, Italy.
Biagio MorettiOrthopaedics Unit, Department DiBraiN, School of Medicine, University of Bari "Aldo Moro", AOU Consorziale Policlinico, 70124 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polydeoxyribonucleotide (PDRN) is a proprietary and registered drug with several beneficial effects, including tissue repairing, anti-ischemic action, and anti-inflammatory properties. The present study aims to summarize the current evidence about PRDN's clinical effectiveness in the management of tendon disorders. From January 2015 to November 2022, OVID-MEDLINE

Indexed as

Achilles TendonRotator Cuff InjuriesTendinopathyChronic DiseaseHumansMalePolydeoxyribonucleotidesRotator CuffTreatment OutcomePolydeoxyribonucleotidesAchilles tendinopathyESWTfasciitislateral epicondylitismusculoskeletal painPDRNrotator cuff diseasetendinitistendinopathiestendon diseases

Identifiers

PMID36902012
PMCPMC10002571

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read8
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.