Evidence map›Paper›PMID 36904147›Full record

ArticleNutrients2023

Beta-Hydroxybutyrate (BHB), Glucose, Insulin, Octanoate (C8), and Decanoate (C10) Responses to a Medium-Chain Triglyceride (MCT) Oil with and without Glucose: A Single-Center Study in Healthy Adults.

Christina Heidt, Manfred Fobker, Mary Newport, Reinhold Feldmann, Tobias Fischer, Thorsten Marquardt

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In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christina HeidtDepartment of Pediatrics, University Hospital Muenster, 48149 Muenster, Germany.ORCID 0000-0002-1547-3973
Manfred FobkerCentre of Laboratory Medicine, University Hospital Muenster, 48149 Muenster, Germany.
Mary NewportSpring Hill Neonatology, Inc., Spring Hill, FL 34610, USA.
Reinhold FeldmannDepartment of Pediatrics, University Hospital Muenster, 48149 Muenster, Germany.
Tobias FischerDepartment of Food, Nutrition and Facilities, FH Muenster, University of Applied Sciences, 48149 Muenster, Germany.ORCID 0000-0001-9027-2461
Thorsten MarquardtDepartment of Pediatrics, University Hospital Muenster, 48149 Muenster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MCTs are increasingly being used to promote ketogenesis by patients on ketogenic diet therapy, but also by people with other conditions and by the general public for the perceived potential benefits. However, consumption of carbohydrates with MCTs and untoward gastrointestinal side effects, especially at higher doses, could decrease the sustainability of the ketogenic response. This single-center study investigated the impact of consuming carbohydrate as glucose with MCT oil compared to MCT alone on the BHB response. The effects of MCT oil versus MCT oil plus glucose on blood glucose, insulin response, levels of C8, C10, BHB, and cognitive function were determined, and side effects were monitored. A significant plasma BHB increase with a peak at 60 min was observed in 19 healthy participants (24.4 ± 3.9 years) after consuming MCT oil alone, and a more delayed but slightly higher peak was observed after consuming MCT oil plus glucose. A significant increase in blood glucose and insulin levels occurred only after MCT oil plus glucose intake. The overall mean plasma levels of C8 and C10 were higher with the intake of MCT oil alone. MCT oil plus glucose consumption showed improved scores for the arithmetic and vocabulary subtests.

Indexed as

CaprylatesGlucose3-Hydroxybutyric AcidAdultBlood GlucoseDecanoatesHumansInsulinKetone BodiesTriglycerides3-Hydroxybutyric AcidBlood GlucoseCaprylatesDecanoatesGlucoseInsulinKetone Bodiesoctanoic acidTriglyceridesbeta-hydroxybutyratecognitive functiondecanoic acidglucoseinsulinketogenic dietmedium-chain fatty acidsoctanoic acid

Identifiers

PMID36904147
PMCPMC10005646

What Socratic holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read59
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.