Evidence map›Paper›PMID 36906514›Full record

ArticleAdvanced healthcare materials2023

Outersphere Approach to Increasing the Persistance of Oxygen-Sensitive Europium(II)-Containing Contrast Agents for Magnetic Resonance Imaging with Perfluorocarbon Nanoemulsions toward Imaging of Hypoxia.

Jacob C Lutter, Andrea L Batchev, Caitlyn J Ortiz, Alexander G Sertage, Jonathan Romero, S A Amali S Subasinghe, Steen E Pedersen, Md Abul Hassan Samee, Robia G Pautler, Matthew J Allen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Single Molecule EuJournal of the American Chemical Society · 2026
    Article
  2. Article
  3. Article
  4. Reversible Enzymatic Switching of the Oxidation State of a EuJournal of the American Chemical Society · 2025
    Article
  5. Hypoxia Imaging as a Radiomics Signature in Tumors Using NovelbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jacob C LutterDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
Andrea L BatchevDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
Caitlyn J OrtizDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, 77030, USA.
Alexander G SertageDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
Jonathan RomeroDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, 77030, USA.
S A Amali S SubasingheDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
Steen E PedersenDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, 77030, USA.
Md Abul Hassan SameeDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, 77030, USA.
Robia G PautlerDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX, 77030, USA.
Matthew J AllenDepartment of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.ORCID 0000-0002-6868-8759

Funding

Intratumoral imaging of hypoxia using 1H- and 19F-MRI with redox-responsive Eu-based contrast agentsR01EB026453 · NIBIB · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J, PAUTLER, ROBIA G · 2018 to 2021
$2.7M
Library Synthesis and Screening of Eu(II)-Based Contrast AgentsR01EB027103 · NIBIB · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J · 2019 to 2022
$1.4M
Chemistry Biology Interface Training Program at Wayne State UniversityT32GM142519 · NIGMS · WAYNE STATE UNIVERSITY · PI CHOW, CHRISTINE S, PFLUM, MARY KAY H · 2021 to 2025
$1.2M
500 MHz NMR SpectrometerS10OD028488 · OD · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J · 2021 to 2021
$600k
NIBIB NIH HHS R01 EB026453NIBIB NIH HHS R01 EB027103NIGMS NIH HHS T32 GM142519NIH HHS S10 OD028488
6 · The paper itself

Abstract

Radiographic mapping of hypoxia is needed to study a wide range of diseases. Complexes of Eu(II) are a promising class of molecules to fit this need, but they are generally limited by their rapid oxidation rates in vivo. Here, a perfluorocarbon-nanoemulsion perfused with N

Indexed as

EuropiumFluorocarbonsContrast MediaHumansHypoxiaMagnetic Resonance ImagingOxygenContrast MediaEuropiumFluorocarbonsOxygenEu(II)hypoxiaMRIperfluorocarbons

Identifiers

PMID36906514
PMCPMC10440236

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.