Evidence map›Paper›PMID 36907972›Full record

ArticleNeurochemical research2023

Glycogen Synthase Kinase-3 Inhibitors Block Morphine-Induced Locomotor Activation, Straub Tail, and Depression of Rearing in Mice Via a Possible Central Action.

Junichi Kitanaka, Nobue Kitanaka, Kazuo Tomita, F Scott Hall, Kento Igarashi, George R Uhl, Tomoaki Sato

Abstract read
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In one paragraph

Article in Neurochemical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. A Fentanyl-Responsive Microneedle Patch for Harm Reduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Junichi Kitanaka *Laboratory of Drug Addiction and Experimental Therapeutics, Department of Pharmacy, School of Pharmacy, Hyogo Medical University, 1-3-6 Minatojima, Chuo-ku, Kobe, Hyogo, 650-8530, Japan. kitanaka-hyg@umin.net.
Nobue Kitanaka *Department of Pharmacology, School of Medicine, Hyogo Medical University, Nishinomiya, Hyogo, 663-8501, Japan.
Kazuo Tomita *Department of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan.
F Scott HallDepartment of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, 43614, USA.
Kento IgarashiDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan.
George R UhlVA Maryland Healthcare System, Baltimore, MD, 21201, USA.
Tomoaki SatoDepartment of Applied Pharmacology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan.
Kagoshima University · JPHyogo University · JPUniversity of Maryland, Baltimore · USUniversity of Toledo · US

Funding

Japan Society for the Promotion of Science 21K06591Japan Society for the Promotion of Science 22K10151
6 · The paper itself

Abstract

We investigated morphine-induced Straub's tail reaction (STR) in mice pretreated with or without glycogen synthase kinase-3 (GSK-3) inhibitors (SB216763 and AR-A014418) by using a newly modified, infrared beam sensor-based automated apparatus. Mice treated with a single injection of morphine (30 mg/kg, i.p.) showed a significant STR with a plateau level at a time point of 20 min after morphine challenge. Pretreatment of mice with SB216763 (5 mg/kg, s.c.) or AR-A014418 (3 mg/kg, i.p.) significantly inhibited morphine-induced STR and attenuated the duration of STR in a dose-dependent fashion. In the striatum and the nucleus accumbens, expression of pGSK-3β

Indexed as

Glycogen Synthase Kinase 3MorphineAnimalsGlycogen Synthase Kinase 3 betaIndolesMaleimidesMiceTailThiazolesUreaGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaIndolesMaleimidesMorphineN-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)ureaSB 216763ThiazolesUreaGlycogen synthase kinase-3HyperlocomotionInfrared beam sensor-based automated apparatusMorphineStraub’s tail reaction

Identifiers

PMID36907972
OpenAlexW4324019789

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.