Evidence map›Paper›PMID 36909574›Full record

ArticlebioRxiv : the preprint server for biology2023

The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting

Robert J Bastidas, Mateusz Kędzior, Robert K Davidson, Stephen C Walsh, Lee Dolat, Barbara S Sixt, Jonathan N Pruneda, Jörn Coers, Raphael H Valdivia

Open access · greenFull text readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Robert J BastidasDepartment of Integrative Immunobiology, Duke University, Durham, N.C 27708, USA.ORCID 0000-0001-9219-572X
Mateusz KędziorDepartment of Integrative Immunobiology, Duke University, Durham, N.C 27708, USA.ORCID 0000-0002-9250-9925
Robert K DavidsonDepartment of Molecular Genetics and Microbiology, Duke University, Durham, N.C 27708, USA.
Stephen C WalshDepartment of Molecular Genetics and Microbiology, Duke University, Durham, N.C 27708, USA.ORCID 0000-0002-6999-8601
Lee DolatDepartment of Integrative Immunobiology, Duke University, Durham, N.C 27708, USA.ORCID 0000-0003-1271-4863
Barbara S SixtDeparment of Molecular Biology, Umeå University, Umeå, Sweden.ORCID 0000-0002-5607-8902
Jonathan N PrunedaDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR 97239, USA.ORCID 0000-0002-0304-4418
Jörn CoersDepartment of Integrative Immunobiology, Duke University, Durham, N.C 27708, USA.ORCID 0000-0001-8707-4608
Raphael H ValdiviaDepartment of Integrative Immunobiology, Duke University, Durham, N.C 27708, USA.ORCID 0000-0003-0961-073X
Duke University · USOregon Health & Science University · USUmeå University · SE

Funding

IRGM-driven host responses to Chlamydia trachomatis infectionsR01AI103197 · NIAID · DUKE UNIVERSITY · PI COERS, JOERN · 2013 to 2023
$4.2M
Exploiting bacterial effector proteins to study human ubiquitin signalingR35GM142486 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jonathan N Pruneda · 2021 to 2026
$2.6M
Functional characterization of early Chlamydia effectorsR01AI134891 · NIAID · DUKE UNIVERSITY · PI VALDIVIA, RAPHAEL H · 2018 to 2022
$2.4M
Interferon-inducible cell-intrinsic host defense against Chlamydia trachomatisR37AI103197 · NIAID · DUKE UNIVERSITY · PI Jorn Coers · 2024 to 2026
$1.6M
Posttranslational modifications of host proteins by Chlamydia effectorsR21AI140019 · NIAID · DUKE UNIVERSITY · PI BASTIDAS, ROBERT J · 2018 to 2019
$441k
NIAID NIH HHS R01 AI103197NIAID NIH HHS R01 AI134891NIAID NIH HHS R21 AI140019NIAID NIH HHS R37 AI103197NIGMS NIH HHS R35 GM142486
6 · The paper itself

Abstract

Many cellular processes are regulated by ubiquitin-mediated proteasomal degradation. Pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen

Identifiers

PMID36909574
PMCPMC10002621
OpenAlexW4322618494

What Socratic holds

Textfull text, public
LicenceCC BY-ND
reference markers read1
measurements read158
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.