Evidence map›Paper›PMID 36909579›Full record

ArticlebioRxiv : the preprint server for biology2023

Type I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection.

Juliana Bragazzi Cunha, Kyle Leix, Emily J Sherman, Carmen Mirabelli, Andrew A Kennedy, Adam S Lauring, Andrew W Tai, Christiane E Wobus, Brian T Emmer

Open access · greenFull text readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Juliana Bragazzi CunhaDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor MI.
Kyle LeixDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor MI.
Emily J ShermanDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor MI.
Carmen MirabelliDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor MI.
Andrew A KennedyDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor MI.
Adam S LauringDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor MI.
Andrew W TaiDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor MI.
Christiane E WobusDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor MI.
Brian T EmmerDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor MI.
University of Michigan · US

Funding

How flaviviruses hijack a host transmembrane protein chaperone to promote viral infectionR01GM139823 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAI, ANDREW W. · 2021 to 2024
$1.4M
Cholesterol regulation by the cargo receptor SURF4K08HL148552 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EMMER, BRIAN T · 2019 to 2023
$788k
NHLBI NIH HHS K08 HL148552NIGMS NIH HHS R01 GM139823
6 · The paper itself

Abstract

Disease progression during SARS-CoV-2 infection is tightly linked to the fate of lung epithelial cells, with severe cases of COVID-19 characterized by direct injury of the alveolar epithelium and an impairment in its regeneration from progenitor cells. The molecular pathways that govern respiratory epithelial cell death and proliferation during SARS-CoV-2 infection, however, remain poorly understood. We now report a high-throughput CRISPR screen for host genetic modifiers of the survival and proliferation of SARS-CoV-2-infected Calu-3 respiratory epithelial cells. The top 4 genes identified in our screen encode components of the same type I interferon signaling complex -

Identifiers

PMID36909579
PMCPMC10002732
OpenAlexW4323032335

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read44
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.