Evidence map›Paper›PMID 36909584›Full record

ArticleResearch square2023

Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity.

XingLiang Zhu, Yuyoung Joo, Simone Bossi, Ross McDevitt, Aoji Xie, Yue Wang, Yutong Xue, Shuaikun Su, Seung Kyu Lee, Nirnath Sah and 10 more

Open access · greenFull text readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

XingLiang ZhuNational Institutes of Health.ORCID 0000-0003-3411-8712
Yuyoung JooNational Institute on Aging.
Simone BossiNational Institute on Aging.
Ross McDevittNational Institute on Aging.
Aoji XieNational Institute on Aging.
Yue WangNational Institute on Aging.
Yutong XueNational Institute on Aging.
Shuaikun SuNational Institute on Aging.
Seung Kyu LeeNational Institute on Aging.
Nirnath SahNational Institute on Aging.
Shiliang ZhangFlorida Atlantic University.
Rong YeFlorida Atlantic University.
Alejandro PintoNational Institute on Aging.
Yongqing ZhangNational Institute on Aging.
Kimi ArakiInstitute of Resource Development and Analysis, Kumamoto University.
Masatake ArakiInstitute of Resource Development and Analysis, Kumamoto University.ORCID 0000-0002-3056-2499
Marisela MoralesNational Institute on Drug Abuse.ORCID 0000-0002-3845-9402
Mark MattsonDepartment of Neuroscience, Johns Hopkins University School of Medicine.
Henriette van PraagFlorida Atlantic University.ORCID 0000-0002-5727-434X
Weidong WangNational Institute on Aging.ORCID 0000-0002-0658-7928
Institute on Aging · USFlorida Atlantic University · USKumamoto University · JPJohns Hopkins University · USNational Institute on Drug Abuse · USNational Institutes of Health · US

Funding

Investigation of an RNA topoisomerase complex involved in Fragile X syndromeZIAAG000689 · NIA · NATIONAL INSTITUTE ON AGING · PI WANG, WEIDONG · 2011 to 2025
$6.9M
ISOLATION OF PROTEIN COMPLEX INVOLVED IN BLOOM SYNDROMEZ01AG000657 · NIA · NATIONAL INSTITUTE ON AGING · PI WANG, WEIDONG · 2000 to 2008
$636k
Intramural NIH HHS Z01 AG000657
6 · The paper itself

Abstract

The Topoisomerase 3B (Top3b) - Tudor domain containing 3 (Tdrd3) protein complex is the only dual-activity topoisomerase complex in animals that can alter the topology of both DNA and RNA.

Indexed as

myelinationneurogenesisneurological disordersTdrd3Top3b

Identifiers

PMID36909584
PMCPMC10002826
OpenAlexW4322766708

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read101
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.