Evidence map›Paper›PMID 36909625›Full record

ArticlebioRxiv : the preprint server for biology2023

Metagenome diversity illuminates origins of pathogen effectors.

Victoria I Verhoeve, Stephanie S Lehman, Timothy P Driscoll, John F Beckmann, Joseph J Gillespie

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Victoria I VerhoeveDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Stephanie S LehmanDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
Timothy P DriscollDepartment of Biology, West Virginia University, Morgantown, West Virginia, USA.
John F BeckmannMicrobiology and Immunology, University of South Alabama, Mobile, AL, USA.
Joseph J GillespieDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
University of Maryland, Baltimore · USNational Institutes of Health · USUniversity of South Alabama · USWest Virginia University · US

Funding

Characterizing the Pan-genome of a Rickettsia Infecting the Eastern Black-legged TickR21AI156762 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DRISCOLL, TIMOTHY P, GILLESPIE, JOSEPH J · 2021 to 2022
$435k
Rickettsia cell envelope glycoconjugates are derived from the host cell amino sugar biosynthesis pathwayR21AI146773 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GILLESPIE, JOSEPH J, RAHMAN, MOHAMMED SAYEEDUR · 2019 to 2020
$425k
Investigating Rickettsia Interspecies and Host-Specific Lipopolysaccharide VariationR21AI166832 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GILLESPIE, JOSEPH J · 2022 to 2023
$425k
Characterizing gene family expansion in an atypical bacterial secretion systemR21AI126108 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GILLESPIE, JOSEPH J, RAHMAN, MOHAMMED SAYEEDUR · 2016 to 2017
$424k
NIAID NIH HHS R21 AI156762NIAID NIH HHS R21 AI166832
6 · The paper itself

Abstract

Recent metagenome assembled genome (MAG) analyses have profoundly impacted Rickettsiology systematics. Discovery of basal lineages (Mitibacteraceae and Athabascaceae) with predicted extracellular lifestyles reveals an evolutionary timepoint for the transition to host dependency, which occurred independent of mitochondrial evolution. Notably, these basal rickettsiae carry the Rickettsiales

Indexed as

effectorevolutionmetagenomeRickettsiatype IV secretion system

Identifiers

PMID36909625
PMCPMC10002696
OpenAlexW4322489558

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.