Evidence map›Paper›PMID 36911657›Full record

ArticleJournal of virus eradication2023

Barriers that prevent adults living with HBV infection from participating in clinical research: experience from South Africa.

Nombuyiselo Mofokeng, Tongai G Maponga, Marije van Schalkwyk, Susan Hugo, Molefi Daniel Morobadi, Sabeehah Vawda, Leane Badenhorst, Cloete van Vuuren, Christo van Rensburg, Wolfgang Preiser and 8 more

Abstract read
In one paragraph

Article in Journal of virus eradication, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. The People-First Liver Charter.Nature medicine · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nombuyiselo MofokengUniversity of the Free State, Nelson Mandela Drive, Bloemfontein, 9300, South Africa.
Tongai G MapongaDivision of Medical Virology, University of Stellenbosch, Tygerberg Hospital, Francie Van Zijl Drive, Cape Town, 7505, South Africa.
Marije van SchalkwykDivision of Infectious Diseases, Department of Medicine, Stellenbosch University / Tygerberg Academic Hospital, Cape Town, South Africa.
Susan HugoDivision of Infectious Diseases, Department of Medicine, Stellenbosch University / Tygerberg Academic Hospital, Cape Town, South Africa.
Molefi Daniel MorobadiUniversity of the Free State, Nelson Mandela Drive, Bloemfontein, 9300, South Africa.
Sabeehah VawdaUniversity of the Free State, Nelson Mandela Drive, Bloemfontein, 9300, South Africa.
Leane BadenhorstUniversity of the Free State, Nelson Mandela Drive, Bloemfontein, 9300, South Africa.
Cloete van VuurenUniversity of the Free State, Nelson Mandela Drive, Bloemfontein, 9300, South Africa.
Christo van RensburgDivision of Gastroenterology, Department of Medicine, Stellenbosch University / Tygerberg Academic Hospital, Cape Town, South Africa.
Wolfgang PreiserDivision of Medical Virology, University of Stellenbosch, Tygerberg Hospital, Francie Van Zijl Drive, Cape Town, 7505, South Africa.
Jantjie TaljaardDivision of Infectious Diseases, Department of Medicine, Stellenbosch University / Tygerberg Academic Hospital, Cape Town, South Africa.
Su WangCooperman Barnabas Medical Center, Florham Park, NJ, USA.
Veronica MillerUniversity of California Berkeley School of Public Health, 2121 Berkeley Way, Berkeley, CA, 94704, USA.
Dan WuClinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK.
Joseph D TuckerClinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK.
Janet SeeleyDepartment of Global Health and Development, Faculty of Public Health and Policy, School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK.
Dominique GoedhalsUniversity of the Free State, Nelson Mandela Drive, Bloemfontein, 9300, South Africa.
Philippa C MatthewsNuffield Department of Medicine, University of Oxford, OX1 3SY, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High profile international goals have been set for the elimination of hepatitis B virus (HBV) infection as a public health threat by the year 2030. Developing and expanding equitable, accessible translational HBV research programmes that represent real-world populations are therefore an urgent priority for clinical and academic communities. We present experiences and insights by an expert interdisciplinary group focusing on barriers that impede adults living with HBV infection from participating in clinical studies. Our viewpoint describes barriers we have identified through working in a variety of settings across South Africa, including lack of education and awareness, experiences of stigma and discrimination, challenges for governance and data management, and a burden of complex morbidity. Through identifying these challenges, we propose solutions and interventions, highlight new approaches, and provide a framework for future research.

Indexed as

BarriersClinical researcheHealth, Electronic HealthEliminationEquityEthicsHBVHBV, Hepatitis B VirusHCV, Hepatitis C VirusHCW, Healthcare WorkersHepatitis B virusHIV, Human Immunodeficiency VirusLMICSouth AfricaTB, TuberculosisTrialsWHO, World Health Organization

Identifiers

PMID36911657
PMCPMC9995934

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.