ArticleAmerican journal of respiratory and critical care medicine2023
SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.
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Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- RELM-β Augmented Hypoxia-Induced Pulmonary Hypertension Through Interacting with GIPC1, OR1N1 and CLIC4.Cardiovascular drugs and therapy · 2026Article
- Variation inCirculation research · 2026Article
- Experimental pulmonary arterial hypertension in mice with a pathogenic SOX17 variant.Scientific reports · 2026Article
- Advances in the pathogenesis and clinical management of pulmonary hypertension.Medical review (2021) · 2026Review
- A second-hit conceptual framework for pulmonary arterial hypertension in adult congenital heart disease: genetics, hemodynamics, and treat-and-repair.Frontiers in cardiovascular medicine · 2026Review
- Pathophysiology of Pulmonary Arterial Hypertension: Focus on Vascular Endothelium as a Potential Therapeutic Target.International journal of molecular sciences · 2025Review
- Metformin suppresses the mitochondrial and transcriptional response to exercise, revealing a conserved BCL6B-associated angiogenic program.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Metabolic Disturbances Involved in Cardiovascular Diseases: The Role of Mitochondrial Dysfunction, Altered Bioenergetics and Oxidative Stress.International journal of molecular sciences · 2025Review
- SOX17 in pulmonary arterial hypertension: from development to clinical phenotype.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Guarding the Endothelium: SOX17's Crucial Role in Pulmonary Hypertension.American journal of respiratory cell and molecular biology · 2025Article
- Review
- Integrating Hypoxia Signatures from scRNA-seq and Bulk Transcriptomes for Prognosis Prediction and Precision Therapy in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma.International journal of molecular sciences · 2025Article
- Impaired sleep efficiency predicts adverse prognosis in elderly pancreatic cancer patients: a retrospective case - control study based on wearable smart devices.American journal of translational research · 2025Article
- Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes.Cellular & molecular biology letters · 2024Review
- Pathology and pathobiology of pulmonary hypertension: current insights and future directions.The European respiratory journal · 2024Review
- CD137 Signaling Mediates Pulmonary Artery Endothelial Cell Proliferation Under Hypoxia By Regulating Mitochondrial Dynamics.Journal of cardiovascular translational research · 2024Article
- Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension.Circulation · 2024Article
- Endothelial Function in Pulmonary Arterial Hypertension: From Bench to Bedside.Journal of clinical medicine · 2024Review
- Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia.International journal of molecular sciences · 2024Article
- Identification of potential biomarkers for idiopathic pulmonary arterial hypertension using single-cell and bulk RNA sequencing analysis.Frontiers in genetics · 2024Article
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Authors and funding
29 authors at 10 institutions in 3 countries.
Shreya SangamDepartment of Medicine and.
Xutong SunCenter for Translational Science, Florida International University, Port Saint Lucie, Florida.
Tae-Hwi Schwantes-AnDepartment of Medical & Molecular Genetics, Indiana University, Indianapolis, Indiana.
Manivannan YegambaramCenter for Translational Science, Florida International University, Port Saint Lucie, Florida.
Qing LuCenter for Translational Science, Florida International University, Port Saint Lucie, Florida.
Yinan ShiDepartment of Medicine and.
Todd CookDepartment of Medicine and.
Amanda FisherDepartment of Medicine and.
Andrea L FrumpDepartment of Medicine and.
Anna ColemanDivision of Human Genetics, Cincinnati Children's Hospital Medical Center and.
Yanan SunState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Shuxin LiangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Howard CrawfordHenry Ford Pancreatic Cancer Center, Henry Ford Hospital, Detroit, Michigan.
Katie A LutzDivision of Human Genetics, Cincinnati Children's Hospital Medical Center and.
Avinash D MaunDepartment of Medicine and.
Michael W PauciuloDivision of Human Genetics, Cincinnati Children's Hospital Medical Center and.
Jason H KarnesDepartment of Pharmacy Practice and Science, R. Ken Coit College of Pharmacy, and.
Ketul R ChaudharyDepartment of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0003-1725-7438
Duncan J StewartDepartment of Medicine, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Paul R LanglaisDivision of Endocrinology, College of Medicine, University of Arizona, Tucson, Arizona.
Mohit JainDepartment of Medicine and.
Mona AlotaibiDepartment of Medicine and.
Tim LahmDepartment of Medicine and.
Yan JinCenter for Translational Science, Florida International University, Port Saint Lucie, Florida.
Haiwei GuCenter for Translational Science, Florida International University, Port Saint Lucie, Florida.
Haiyang TangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
William C NicholsDivision of Human Genetics, Cincinnati Children's Hospital Medical Center and.
Stephen M BlackCenter for Translational Science, Florida International University, Port Saint Lucie, Florida.
Ankit A DesaiDepartment of Medicine and.
Florida International University · USCincinnati Children's Hospital Medical Center · USFirst Affiliated Hospital of Guangzhou Medical University · CNDalhousie University · CAHenry Ford Hospital · USIndiana University – Purdue University Indianapolis · USNational Jewish Health · USOttawa Hospital · CAUniversity of Arizona · USUniversity of California System · US
Funding
TGF-ß-SOX18-Collagen metabolism in pulmonary vascular disease associated with CHDP01HL146369 · NHLBI · UNIVERSITY OF ARIZONA · PI JEFFREY R FINEMAN · 2020 to 2026
$18.7MProtein Chemistry & Biophysics CoreP01HL134610 · NHLBI · UNIVERSITY OF ARIZONA · PI BLACK, STEPHEN M · 2018 to 2022
$11.6MNational Biological Sample and Data Repository for PAHR24HL105333 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI NICHOLS, WILLIAM C · 2012 to 2016
$10.1MPERINATAL REGULATION OF THE ENDOTHELIAL NOS GENER01HL060190 · NHLBI · UNIVERSITY OF MONTANA · PI Stephen M Black · 1998 to 2026
$7.1MDevelopmental PBDE exposure, gut microbiome, and diabetesR01ES030197 · NIEHS · UNIVERSITY OF WASHINGTON · PI Julia Yue Cui, Haiwei Gu · 2019 to 2026
$5.0MMechanisms of Right Ventricle Adaptation to Pulmonary HypertensionR01HL144727 · NHLBI · NATIONAL JEWISH HEALTH · PI Tim Lahm · 2019 to 2026
$4.7MThe emerging role of apelin, RAAS, and ACE2 crosstalk in pulmonary hypertensionR01HL164791 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Andrea Lee Frump · 2022 to 2026
$3.8MRisk stratification in pulmonary arterial hypertension: Intersection of OMICs and longitudinal phenotypes through the PAH BiobankR01HL160941 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI DESAI, ANKIT A, NICHOLS, WILLIAM C · 2022 to 2025
$3.2MPerinatal NO signaling in congenital heart diseaseR01HL137282 · NHLBI · UNIVERSITY OF ARIZONA · PI BLACK, STEPHEN M, FINEMAN, JEFFREY R · 2017 to 2020
$2.7MPathogenic Role of IL-18 in Sickle Cell Cardiomyopathy and Inducible Ventricular TachycardiaR01HL136603 · NHLBI · UNIVERSITY OF ARIZONA · PI DESAI, ANKIT A · 2017 to 2021
$2.4MLeveraging the Microbiome, Local Admixture, and Machine Learning to Optimize Anticoagulant Pharmacogenomics in Medically Underserved PatientsR01HL158686 · NHLBI · UNIVERSITY OF ARIZONA · PI KARNES, JASON HANSEN · 2021 to 2025
$2.2MABO and Immunogenetic Variation in the Pathogenesis of Heparin-Induced ThrombocytopeniaR01HL156993 · NHLBI · UNIVERSITY OF ARIZONA · PI KARNES, JASON HANSEN · 2022 to 2025
$2.0MBLRD VA I01 BX002042NHLBI NIH HHS 1R01HL144727NHLBI NIH HHS P01 HL134610NHLBI NIH HHS P01 HL146369NHLBI NIH HHS R01 HL060190NHLBI NIH HHS R01 HL136603NHLBI NIH HHS R01 HL137282NHLBI NIH HHS R01 HL142212NHLBI NIH HHS R01 HL144727NHLBI NIH HHS R01 HL156993NHLBI NIH HHS R01 HL158686NHLBI NIH HHS R01 HL160941NHLBI NIH HHS R01 HL164791NHLBI NIH HHS R24 HL105333NIEHS NIH HHS R01 ES030197NIH HHS R01 HL136603
Abstract
PubMed holds no abstract for this paper.
Indexed as
Hypertension, PulmonaryPulmonary Arterial HypertensionAnimalsEndothelial CellsEstrogensFamilial Primary Pulmonary HypertensionFemaleHMGB ProteinsHypoxiaLungMaleMicePulmonary ArteryRatsSOXF Transcription FactorsEstrogensHMGB ProteinsSox17 protein, mouseSOXF Transcription Factors16α-hydroxyestronehypoxia-inducible factor 2αmetabolismpulmonary arterial hypertensionSRY-related HMG-box 17
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.